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rno-mir-93: Rno-mir-93 is a microRNA that has been studied in various contexts. It has been found that the expression patterns of most miRNAs, including rno-mir-93, revealed by qPCR were consistent with deep-sequencing results, with only a few exceptions [PMC3441217]. Expression data from microRNA.org showed that rno-mir-93 is expressed in the embryonic and adult hippocampus, among other tissues [PMC4122175]. In the development of heart failure with preserved ejection fraction (HFpEF), several non-coding RNAs, including rno-mir-93, were strongly associated [PMC7667132]. Rno-mir-93 was found to be downregulated in the spinal cord of rats with chronic constriction injury (CCI), and its overexpression reduced the expression of Stat3 both in vitro and in vivo [PMC8914318]. The downregulation of rno-mir-93 and upregulation of Stat3 were implicated in the development of neuropathic pain [PMC8914318]. Additionally, overexpression of Stat3 reversed the repressive effects on neuropathic pain development and neuroinflammation induced by rno-mir-93 overexpression [PMC8914318]. The sequences for rno-mir-93 agomirs used were provided as well as a negative control for these agomirs [PMC6522868].
In summary, rno-mir-93 is a microRNA that has been implicated in various biological processes such as heart failure development and neuropathic pain. It exhibits consistent expression patterns with deep sequencing results and is expressed in tissues such as the hippocampus. Rno-mir-93 targets Stat3 and its downregulation contributes to neuropathic pain development. Overexpression of Stat3 can reverse these effects. The sequences for rno-miR-93 agomirs and a negative control were also provided [PMC3441217][PMC4122175][PMC7667132][PMC8914318][PMC6522868].
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