rno-mir-376a: Rno-mir-376a is a microRNA that has been studied in the context of islet stimulation and ovarian regulation. In the Wistar islet, there are three observed trends in miRNA expression changes upon stimulation, including increasing levels of rno-mir-376a [PMC3072418]. However, in the GK islet, there are failures in achieving normal levels of miRNAs, including rno-mir-376a [PMC3072418]. Rno-mir-376a has been found to decrease GRP78 protein production by translational repression without altering GRP78 mRNA levels [PMC4184830]. It has also been shown to bind to the 3'-end of GRP78 mRNA and block its translation [PMC4184830]. Rno-mir-376a expression is induced by hCG and leads to repression of GRP78 translation [PMC4184830]. In granulosa cells, rno-mir-376a has a significant impact on the regulation of GRP78 protein expression but not gene expression [PMC4184830]. It has been identified as one of several miRNAs that bind to the 3'-UTR of GRP78 mRNA and may constitute a network involved in its regulation [PMC4184830]. The luciferase activity in cells transfected with a reporter vector containing the putative rno-mir-376a binding site was reduced by approximately 50% after transfection with precursor [PMC4184830]. Rno-miR-144, rno-mir-376a, and rno-miR-451 have also been studied for their effects on GRP78 mRNA expression in granulosa cells isolated from DES-treated rats [PMC4184830].