LINC01564: LINC01564 is a long non-coding RNA (lncRNA) that is involved in a positive feedback regulation with POU2F1, a transcription factor. POU2F1 promotes the expression of LINC01564 through transcriptional activation, and in turn, LINC01564 stabilizes the mRNA of POU2F1 [PMC9101833]. A prognostic risk score called GILncSig was developed based on four genomic instability-associated lncRNAs, including LINC01564. The risk score calculation includes the expression levels of AC023310.4, AC091729.1, LINC01564, and MIR3142HG [PMC8812830]. These findings suggest that POU2F1 enhances the metastatic ability of gastric cancer (GC) cells in vivo and that knockdown of LINC01564 inhibits POU2F1 expression and metastasis [PMC9101833]. LncRNAs like LINC01564 have been increasingly recognized for their regulatory roles in various biological processes. They can interact with proteins or other RNA molecules to modulate gene expression and cellular functions [PMC9101833]. The positive feedback regulation between POU2F1 and LINC01564 highlights their interplay in gene regulation [PMC9101833]. The GILncSig risk score provides a potential prognostic tool for assessing the genomic instability-associated lncRNAs' impact on cancer outcomes [PMC8812830]. Overall, these findings contribute to our understanding of the regulatory mechanisms involving lncRNAs like LINC01564 and their potential implications in cancer progression and prognosis. Further research is needed to elucidate the precise mechanisms by which these molecules interact and their roles in disease development.
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