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Homo sapiens (human) HOXC cluster antisense RNA 2 (HOXC-AS2) URS00000F783F_9606

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HOXC-AS2: HOXC-AS2 is a long non-coding RNA (lncRNA) that has been implicated in the regulation of glioma epithelial-mesenchymal transition (EMT) progress [PMC6754333]. In a study, the researchers performed a Western blot assay and observed that the knockdown of HOXC-AS2 led to a down-regulation of Vimentin, N-cadherin, and ZEB1 expression in glioma cells [PMC6754333]. This suggests that HOXC-AS2 may play a role in promoting EMT by regulating these proteins. Furthermore, the study found a positive correlation between HOXC-AS2 and ZEB1 levels [PMC6754333]. This indicates that HOXC-AS2 may interact with ZEB1 to regulate EMT in glioma cells. References: [PMC6754333] Wang, Y., Wang, Y., Li, J., Zhang, Y., Yin, H., Han, B., ... & Zhang, J. (2019). Long noncoding RNA HOXC‐AS2 promotes epithelial‐mesenchymal transition via ZEB1 pathway in glioma cells. Journal of cellular biochemistry, 120(6), 10319-10327.

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