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mmu-mir-25: Mmu-mir-25 is a microRNA that is downregulated in DIO mice [PMC4571067]. It is also found to be more prominent and may play crucial roles in the regulatory network [PMC3692539]. Mmu-mir-25 has been extensively expressed during superovulation [PMC4499447]. It is a member of the miR-106b~25 cluster and is located in the 13th intron of the MCM7 gene [PMC7803573]. Overexpression of mmu-mir-25 has been shown to enhance iPSC generation, while knockdown of mmu-mir-25 decreases reprogramming efficiency [PMC8946776]. The precursor sequence of mmu-mir-25, along with upstream and downstream flanking regions, has been amplified from mouse genomic DNA [PMC8355162]. Inhibition of mmu-mir-25 increases reactive oxygen species levels and overexpression of Nox4 [PMC8914318]. Mmu-mir-25 has also been found to be decreased in mice with diabetic peripheral neuropathy [PMC8914318]. Trizol purified RNA was used to clean up miRNA samples, including mmu-mir-25, for expression profiling experiments using Illumina BeadChips [PMC3422281].
In summary, mmu-mir-25 is a downregulated microRNA in DIO mice that may play crucial roles in regulatory networks. It is expressed during superovulation and its overexpression enhances iPSC generation. Inhibition of mmu-mir-25 increases reactive oxygen species levels. Additionally, it has been found to be decreased in mice with diabetic peripheral neuropathy. The precursor sequence of mmu-miR-106b~25 cluster member mmu-miR-25 has been amplified from mouse genomic DNA for further analysis. Trizol purified RNA was used for expression profiling experiments involving mmu-mir-25. [PMC4571067] [PMC3692539] [PMC4499447] [PMC7803573] [PMC8946776] [PMC8355162] [PMC8914318] [PMC3422281].
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