gga-mir-383: Gga-mir-383 is a specific miRNA that targets the 3′UTR region of cDNMT3B [PMC3086922]. In a study examining the regulation of cDNMT3B expression, gga-mir-383, along with gga-miR-15c, gga-miR-29b, and gga-miR-222, was selected for analysis [PMC3086922]. The expression levels of these miRNAs were examined during meiotic stages of germ line development using qRT-PCR [PMC3086922]. The study found that gga-mir-383, along with gga-miR-29b and gga-miR-222, may cause significant downregulation of cDNMT3B in vitro [PMC3086922]. Additionally, the study generated mutants for each miRNA binding site in the cDNMT3B 3′UTR and found that gga-mir-383 resulted in a slight decrease in cDNMT3B expression [PMC3086922]. The regulation of cDNMT3B using these miRNAs is of great interest in this study [PMC3086922]. Furthermore, another study examined the expression patterns of various miRNAs during meiotic stages of germ line development and found that the expressions of gga-miR-15c, gga-mir-383, and gga-miR-222 were increased after E11.5 in males [PMC3086922]. These findings suggest that these miRNAs may downregulate cDNMT3B in vivo in both male and female chickens during germ line development [PMC3086922]. In another analysis comparing different groups (NC versus CS and CM versus CS), it was found that only three miRNAs (including gga-mir-383) were significantly differently expressed in all three groups [PMC5203650]. The expression patterns of gga-miR-21, gga-miR-146b-5p, gga-miR-146b-3p, gga-miR-429, and gga-miR-215 were comparable to the sequencing results [PMC5203650].
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