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Homo sapiens (human) prostate cancer associated transcript 1 (PCAT1) URS00000C0582_9606

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PCAT1: PCAT1 is a long non-coding RNA (lncRNA) that has been extensively studied in various contexts. It has been shown to promote epithelial-mesenchymal transition (EMT) in osteosarcoma cells when overexpressed, while its downregulation suppresses EMT [PMC5797453]. In periodontal ligament stem cells (PDLSCs), PCAT1 has been found to positively regulate osteogenesis by sponging miRNAs [PMC8063120]. PCAT1 is involved in the processing of the CtA polypeptide, which is important for cargo transport [PMC8277102]. It has also been shown to interact with the SOX2 promoter sequences and activate the expression of SLC7A11, thereby enhancing chemotherapy resistance [PMC9005924]. PCAT1 plays a critical role in the interplay between AKT and AR signaling pathways [PMC6486551]. In various cancer types, including cervical cancer and prostate cancer, PCAT1 knockdown has been found to affect radiosensitivity and resensitize resistant cells to chemotherapy [PMC7568621] [PMC8985761]. Additionally, PCAT1 has been implicated in promoting cell proliferation and invasion while inhibiting apoptosis in A549 lung cancer cells [PMC7818005]. It is also involved in the regulation of miRNAs and mRNAs associated with prostate cancer progression [PMC10043306]. Furthermore, PCAT1 interacts with miR-326 and promotes tumor proliferation through ceRNA interaction in esophageal squamous cell carcinoma (ESCC) cells [PMC6609620] [PMC8885534]. Overall, these studies highlight the diverse roles of PCAT1 in various cellular processes and its potential as a therapeutic target for different types of cancers.

Genome locations

Gene Ontology annotations

Sequence

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ACACAUGGAUAUUGGAUAUCUGCAUAGGCAGCUUGCUCCACGCCGGUGCCUACCUGUGCAGAUGGGAAGGAAAGGAAAGUGGCAAGGAGGCAGAGAAAGCAUCUGUACCCUUACAAUUUGGUGAGACAAGAAUGUAUGAAUUCCCACAGGUCAAAUUAUAAUGAAGAAAGGAACCUCUCUUGAGUACAAAGAGCUACCUAUGGUGGUCUGGAGCCGGAGGACCACAGCAUCAAAGGAUAUAAGAUGCAUAGCCAACUGAGGAACCUGAGCAAUUAAAGAGAUCCACAGUUAAGUCACACUUAACUGGCACUUGUGGAAGCCCCGCAAGGCCUGAAGGAGAGCUGACAUAGGCACCCCAGAGAGCCAGAAUCUGGAUCCCAUCUUAAUAAGGCCAUGAACACCAGUGGAGAAGAGGCAGAAACACCAAUGGAUAAGGAACAUUCACAUCUUUCUUCCCAUGUGCCUCUAAGUGCCAGUGCAGGCCCCACAGGCCAAGCUACAGGGAGAAAGGAGAUGACGCAAAGGAACCUAACUGGACUUUAAUCACUAGAAGUGAGAAGAGAAAUCUAUUGGAACCUCCCAAGAUAAUGCCAAGGGUCAAAGGGUGCGCAGAUACAUAAGACCAUGGAAAUAAUAUCAGACAAAAAGCAGAUUAGAGCAAUUUUCUUUUUCGAGUUCAAAAUGGGUUAUAAAGCAGCGGAGACAAACCGCAACAUCACCAACGCCUUUGGCCCAGGAACUGCUAAUGAAGGUACAGUGCAGUCACUGUUCAGGAAGUUUUGCAAAGGAGACUAGAGCCUUGAAGAUGAGGAGCAUAGUGACCAGCCAUUGGAAGUCGACAAAGACCAAUUGAGAGGAAUCAUUGAAGCUGAUCAUCUUACAACUACACGAGAAGUUGUCAAAGAACGCAAUGUUGACCAUUGUGUGGUCUUUUCGCAUUUGAAGCAAAUUGGAAAGGUGAAAAACUUGAUAAGUGGGUGCCUUGUGAGCUCAGCAAAAAUCCAAAAAAAUAAUCAUUUUUAAGUGUUGUCUUCUCUUAUUCUACGCAACAACAAUAACCAUUUUGCAAUCGGAUUGUGAUGUGCAAUGAAAAGUGGAUUUGGGGCCGGGCGCGGUGGCUCACGCCUGUAAUCUCAGCACUUUGGAAGGCCAAGGCGGGCAGAUCACGAGGUCAGGAGAUCAAGACCGUCCUGGCUAACACGGUGAAACCCCGUCUCUACUGAAAAUACAAAAAAUUAGCCGGGUGUGGUGGCUGGCGCCUGUAGUCCCAGCUACAGGCUGAGGCAGGAGAAUGGCAUGAACCUGGGAGGCGGAGCUUGCAGUGAGCCGAGACCGUGCCACUGCACUCCAGCCUGGGCGACAGAGCGAUACUCCGUCAAAAAAAAAAAAAAAAAAAAAAAAAGACAAGUGGAUUUUAUAUAUGGCAACCAGCAAUGACCAGCUCAGUGGCUGGACUGAGAAGAAGCUCCAAAGCACUUCCCAAAGCCAAACUUGCACCAAAAAAAAGGUCAGGGUCACUGUUUGGUGGUCUGCUGCUGGUCUGAUCCACCGCUGCUCUCUGAAUCCUGGCAAAACCAUUACAUCUGAGAAGUAUGCUCAACAAAUCAAUGAGCUACGCCAAAAACUGCAGCAUCUGCAGCUGGCAUUGGUCAACAUAACGGGUCCAAUUCUUCUCCACGACAACGCUCAACUGCACCUUGCGCAAGCAGCGCUUCAAAAGUUGAACAAAUUGGGCUACAUAGUUUUUCCUCAUCCGCCAUAUUCACCUGACGUCUUGCCAACUAACUACCACUUCUUCAAGUAUCUCAACAACUUUUUGCAGGGAAAACACUUCCACAACCAGCAGGAUGCAGAACACGCUUUCCAAGAGUUUGUCGAAUCCUGACGCACAGAUUUUUAUGCUACAGGAAUAAACUAACUUAUUUCUCAUUGGCAAAAAUGUGUUGAUUGUAAUGGUUCCUAUUUUGAUGAAUAAAUGUGUGUUUGAGCCUA

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Publications