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hsa-mir-4516: Hsa-mir-4516 is a microRNA that has shown potential as a biomarker for osteoporosis. A ROC analysis revealed an AUC of 0.727 (95% CI 0.613 to 0.841, P = 0.023) for hsa-mir-4516, compared to an AUC of 0.666 (95% CI 0.512 to 0.82, P = 0.058) for hsa-miR-122-5p [PMC5976644]. However, when both microRNAs were included, the AUC improved to 0.752 (95% CI 0.657 to 0.848, P = 0.004), suggesting that the combination of hsa-mir-4516 and hsa-miR-122-5p may have even greater potential as biomarkers for osteoporosis [PMC5976644]. Furthermore, the target sequence for the binding of hsa-mir-4516 is rs1127313 [PMC5635123], while rs1127314 is the target sequence for hsa-miR-363-5p [PMC5635123]. These findings indicate that both hsa-mir-4516 and hsa-miR-363-5p may play a role in osteoporosis and could be further explored as potential biomarkers [PMC5635123].
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