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Equus caballus (horse) eca-miR-223 URS00000B7E30_9796

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eca-mir-223: Eca-mir-223 is a microRNA that has been found to be expressed at higher levels in old diseased mares compared to young diseased mares and healthy control mares [PMC8227551]. It is one of several microRNAs, including eca-miR-155, eca-miR-200a, and eca-miR-205, that have been shown to target inflammatory immune response genes [PMC8227551]. This study is the first to investigate the expression profile of eca-mir-223 in mares with endometritis [PMC8227551]. The study aimed to measure the expression levels of eca-mir-223 and other microRNAs, as well as the concentrations of IL-6, PGF2α, and PGE2 in serum samples from young and old mares with healthy and abnormal uterine status [PMC8227551]. The results showed higher expression levels of eca-mir-223 in old diseased mares compared to young diseased mares and control mares [PMC8227551]. The over-expression of eca-mir-223 was observed in both young and old diseased mares compared to control healthy mares [PMC8227551]. Eca-mir-223 was found only in microvesicles (MVs) according to RNA-seq data, while other microRNAs such as eca-miR-26 and eca-miR-146a were present in both MVs and cells [PMC6434479]. Real-time PCR validated the expression of eca-miR26, ecam-MIR146a, and ECA-MIR223 in MVs compared to cells [PMC6434479]. These findings suggest that ECA-MIR223 could be a potential target for further research on endometritis.

Genome locations

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    Gene Ontology annotations


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    This sequence is found in 18 other species

    1. Bos taurus bta-miR-223
    2. Callithrix jacchus cja-miR-223
    3. Capra hircus chi-miR-223-3p
    4. Chrysemys picta cpi-miR-223-3p
    5. Columba livia cli-miR-223-3p
    6. Gadus morhua (Atlantic cod) gmo-miR-223a-3p
    7. Homo sapiens (human) hsa-miR-223-3p
    8. Mus musculus (house mouse) mmu-miR-223-3p
    9. Tursiops truncatus (common bottlenose dolphin) miR-223