hsa-mir-378e: Hsa-mir-378e is a microRNA that is part of the GMI signature and targets the insulin-like growth factor-1 receptor (IGF1R) [PMC6595612]. It has been identified as a potential biomarker for preeclampsia and diseases related to the endometrium [PMC9601722]. Bioinformatics analysis has predicted 41 targets for hsa-mir-378e, including IGF-1 and mitogen-activated protein kinase 1 (MAPK-1), which are involved in the pathophysiology of preeclampsia [PMC9601722]. Hsa-mir-378e has not been previously indicated as a biomarker for preeclampsia, unlike other miRNAs such as hsa-mir-1246, hsa-mir-203a-3p, and hsa-mir-378c [PMC9601722]. It has also been found to be highly expressed in recurrent implantation failure (RIF) [PMC8344057]. In addition, high levels of hsa-miR-320e, hsa-miR-378e, and hsa-miR630 have been observed in cerebrospinal fluid after subarachnoid hemorrhage [PMC9732100]. Hsa-mir-378e is one of the candidate miRNAs that have shown high expression levels in various diseases such as preeclampsia and cerebrospinal fluid after subarachnoid hemorrhage [PMC5519761] [PMC5028059] [PMC9612944].