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hsa-mir-22: hsa-mir-22 is a highly expressed miRNA in the heart that regulates the expression and function of genes involved in various cardiac processes such as hypertrophy, sarcomere recombination, and metabolic program changes. It also plays a regulatory role in oxidative stress, cardiomyocyte apoptosis, autophagy, hypertrophy, fibrosis, and regeneration [PMC8691998]. In a study using HEK293 cells, it was found that hsa-mir-22 can modulate the activity of NF-κB1-4 and p21-3′UTR luciferase reporter genes [PMC6064715]. In the context of probiotic environment analysis from TCGA and GEO databases, hsa-mir-22 was identified as one of the differentially expressed miRNAs [PMC8806860]. Furthermore, in hepatocellular carcinoma (HCC) tissues with venous metastasis compared to those without venous metastasis, hsa-mir-22 was found to be down-regulated along with several other miRNAs [PMC6287006]. These findings suggest that hsa-mir-22 may have important roles in cardiac function regulation as well as in cancer progression.
mRNA interactions
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