hsa-mir-4736: Hsa-mir-4736 is a microRNA that has been identified as a core miRNA using the Cytohubb package [PMC9452934]. It has been found to significantly decrease in expression by 2.3-fold and target four genes in the IL-8 signaling pathway [PMC8983057]. In a study comparing metastasis and nonmetastasis groups, the expression levels of hsa-mir-4736 were found to be decreased in the metastasis group [PMC9281586]. Hsa-mir-4736 is also among the 43 co-targeting miRNAs identified in another study [PMC7607069]. In a microarray analysis, hsa-mir-4736 was one of the four up-regulated miRNAs selected for further analysis [PMC6518614]. However, qPCR analysis showed no significant intergroup differences in the expression levels of hsa-mir-4736 [PMC6518614]. Hsa-mir-4736 has also been identified as one of the miRNAs with altered levels in both neuronal-derived and total exosomes from ALS patients, providing insight into novel targets for overcoming ALS pathology [PMC8155522]. Additionally, hsa-mir-4736 is among the top 10 ALKBH5 mRNA-targeting miRNAs identified in another study [PMC9013910]. References: [PMC9452934] [PMC8983057] [PMC9281586] [PMC7607069] [PMC6518614] [PMC8155522] [PCM9013910]
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