SNORD58A: SNORD58A is a C/D box small nucleolar RNA (snoRNA) that is involved in the 2'-O-methylation modification of 28S ribosomal RNA (rRNA) [PMC9616492]. It has been found that the expression of SNORD58A is increased in FXR1-overexpressing cells and G0 cells where FXR1 levels are elevated [PMC9616492]. SNORD58A is the most expressed member of the SNORD58 family in various tissues, including brain, breast, ovary, prostate, and skeletal muscle [PMC8178906]. It has been shown that SNORD58A and SNORD58B are involved in directing 2'-O-methylation of 28S rRNA [PMC2817437]. In response to MERS-CoV infection, SNORD58A expression is downregulated but can be upregulated by experimental compounds [PMC8618917]. In patients with primary open-angle glaucoma (PEXG), SNORD58A expression was found to be significantly higher compared to control groups [PMC9454646]. Additionally, SNORD58A has been shown to have differential expression levels in various biological processes and can target genes such as CACNA3, FAM120AOS, RPS2, and TNPO2 [PMC9454646]. The methylation status of specific target nucleotides for snoRNAs including SNORD58A can be analyzed using reverse transcription termination methods [PMC9696202]. References: - PMC9616492 - PMC8178906 - PMC2817437 - PMC8618917 - PMC9454646 - PMC9696202