oar-mir-16b: Oar-mir-16b is a microRNA that has been studied in relation to its expression patterns and target genes in sheep. It has been verified by qRT-PCR in different comparisons, such as MF vs. PF and ML vs. PL, along with other cirRNAs and target miRNAs [PMC8300399]. Oar-mir-16b has been found to be correlated with various novel_circRNAs, such as novel_circ_0003833, novel_circ_0005497, novel_circ_0005617, and others [PMC8300399]. Through competitive endogenous RNA network analysis, target miRNA sites for oar-mir-16b have been identified in circRNAs [PMC8300399]. Oar-mir-16b has also been found to be functionally opposite to the target gene SMAD2 in pituitary cells [PMC8947352]. It has been shown that oar-mir-16b can bind to the lncRNA SM2 and SMAD2 3’-untranslated region [PMC8947352]. In pituitary cells, inhibition of oar-mir-16b promotes cell proliferation and inhibits cell apoptosis [PMC8947352]. The lncRNA SM2 acts as a ceRNA for oar-mir-16b by sponging it and regulating the expression of SMAD2 in pituitary cells [PMC8947352]. Additionally, oar-mir-16b promotes apoptosis but inhibits proliferation of pituitary cells [PMC8947352]. The dual-luciferase reporter assay confirms the direct relationship between oar-mir-16b and the lncRNA SM2 or SMAD2 [PMC8947352].