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TTTY21: TTTY21 is a non-protein coding transcript that has been found to be up-regulated in samples from infertile patients [PMC9444127]. In addition to TTTY21, several other coding and non-coding genes, such as AMELY, PCDH11, SRY, TGIF2LY, TSPY3, and USP9Y, also displayed low expression in samples from fertile patients and high expression in samples from infertile patients [PMC6375207]. Interestingly, a common bimodal pattern of expression was observed for six coding genes (AMELY, PCDH11, SRY, TGIF2LY, TSPY3, and USP9Y) and ten non-coding genes (TTTY2, TTTY4C,TTTY5,TTTY6,TTTY8,TTTY10,TTTY14,TTTY21,TTTY22,andTTTY23), with low expression in fertile patients and high expression associated with infertility [PMC6375207]. Furthermore,KDM5D was found to be over-expressed in males compared to females [PMC3431816]. On the other hand,XIST,KDM5D,andLOC729444 were over-expressed in males compared to females while TTTY21 was under-expressed in females compared to males [PMC3431816]. In summary,the up-regulation of TTTY21 has been observed in infertile patients while it is under-expressed in females compared to males [PMC9444127][PMC3431816][PMC6375207].
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