oar-let-7c: Oar-let-7c, a member of the let-7 family of miRNAs, has been identified in sheep milk extracellular vesicles (EVs) [PMC7070426]. These EVs contain several let-7 family miRNAs, including oar-let-7c [PMC7070426]. In a study, it was found that 14 sheep miRNAs in the top 20, accounting for about 98%, were immune-related, and oar-let-7c was among them [PMC7070426]. The accuracy of the sequencing results for oar-let-7c was verified using real-time quantitative PCR [PMC7070426]. The EDEM1 gene was found to regulate oar-let-7c along with other let-7 family members [PMC9656243]. Additionally, oar-miR99a, oar-miR125b, and oar-miR143 were also present in the study, along with oar-miR10a and oar-miR200b [PMC8872417]. In another study comparing fine wool sheep and Liaoning cashmere goats, oar-miR143 and oar-let-7c were reported to be highly abundant in both groups [PMC8872417]. Interestingly, these miRNAs have also been associated with differing curliness in the hair follicles of Hu sheep and Chinese tan sheep [PMC8872417].
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