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Rattus norvegicus (Norway rat) rno-miR-494-3p URS0000031935_10116

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rno-mir-494: Rno-mir-494 is a microRNA that has been implicated in various processes related to cerebral ischemic injury and neuroprotection [PMC5270432]. It has been shown that electroacupuncture (EA) treatment can mediate the neuroprotective effect of rno-mir-494 in cerebral ischemic injury [PMC5270432]. EA treatment has been found to decrease the expression of rno-mir-494, while other treatments, such as SA treatment, have minimal effects on its levels [PMC5270432]. Overexpression of rno-mir-494 has been shown to decrease the levels of DJ-1 and increase susceptibility to oxidative stress-induced dopaminergic neuronal death [PMC5270432]. Additionally, rno-mir-494 has been found to target various anti-apoptotic proteins, including rno-miR-195, rno-miR-125a-5p, and rno-miR-221 [PMC3682887]. Furthermore, it has been suggested that EA treatment at specific acupuncture points can reverse the upregulation of rno-mir-494 following ischemic stroke [PMC6297779]. Rno-mir-494 may also be involved in the process of neurogenesis and spontaneous recovery following cerebral ischemic injury [PMC6297779]. In other studies, it was found that mechanical stretching can dysregulate the expression of several miRNAs including rno-miR-130b and rno-mir-494 [PMC5856749]. Overall, these findings highlight the importance of rno-mir-494 in cerebral ischemic injury and its potential as a target for neuroprotective interventions.

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