SNORA74B: SNORA74B is a type of small nucleolar RNA (snoRNA) that has been studied in relation to gallbladder cancer (GBC) [PMC5386738]. Higher expression of SNORA74B has been found to be positively associated with increased local invasion, advanced tumor stage, increased carbohydrate antigen 19-9 (CA 19-9) levels, and high expression of Ki67 [PMC5386738]. Conversely, SNORA74B expression was negatively associated with the expression of PHLPP [PMC5386738]. Silencing SNORA74B was found to inhibit proliferation, induce G1 arrest, and promote apoptosis in GBC cells [PMC5386738]. The regulation of PHLPP by SNORA74B may involve RNA-protein interaction and epigenetic suppression mechanisms [PMC5386738]. The relationship between SNORA74B expression and clinicopathological features was analyzed using chi-square analysis [PMC5386738]. Additionally, receiver operating characteristic (ROC) curve analysis was performed to determine the sensitivity and specificity of SNORA74B expression in discriminating tumor tissues from non-tumor tissues [PMC5386738]. The study suggests that if detectable in blood, SNORA74B combined with CA19-9 could serve as valuable diagnostic indicators for GBC [PMC5386738]. In terms of differential gene expression analysis, SNORA74B was not found to be one of the top five most down-regulated microRNAs in GBC cells compared to non-tumor cells [PMC8366141]. The study also investigated the potential molecular mechanisms by which silencing SNORA74B inhibits proliferation and promotes apoptosis by examining the activation of the AKT/mTOR pathway after siRNA knockdown [PMC5386738]. Overall, these findings highlight the potential role of SNORA74B as a diagnostic indicator for GBC and its involvement in regulating cellular processes in GBC cells [PMC5386738][PMC8366141].
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