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Homo sapiens (human) long intergenic non-protein coding RNA 1569 (LINC01569) URS000000B904_9606

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LINC01569: LINC01569, a long non-coding RNA, has been implicated as a potential carcinogen through its interaction with miR-381-3p [PMC8378226]. Research has shown a significant increase in the expression of LINC01569 in patients with colorectal cancer (CRC) [PMC8378226]. The role of LINC01569 in the regulation of mechanosensors and its potential binding to the glucocorticoid receptor (GR) has also been investigated [PMC7904261]. Previous studies have demonstrated that LINC01569 can mediate glucocorticoid effects on mechanotransduction by destabilizing messenger RNA (mRNA) of mechanosensors [PMC8378226]. LINC01569 is a long non-coding RNA that has been implicated in cancer development and progression. It is suggested that LINC01569 may act as a carcinogen by sponging miR-381-3p, thereby affecting downstream signaling pathways [PMC8378226]. In this particular study, the expression of LINC01569 was found to be significantly increased in patients with CRC, indicating its potential role as a biomarker for this disease [PMC8378226]. Furthermore, the researchers investigated whether LINC01569 could mediate glucocorticoid-induced effects on mechanosensors. It was hypothesized that LINC01569 may regulate or bind to the GR to modulate gene expression and downstream signaling pathways involved in mechanotransduction [PMC7904261]. Previous studies have also shown that LINC01569 can destabilize mRNA of mechanosensors, thereby affecting their expression and function. This suggests that LINC01569 may play a role in modulating cellular responses to mechanical stimuli through its interaction with mRNA molecules involved in mechanotransduction pathways [PMC8378226].

Genome locations

Gene Ontology annotations

Sequence

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GGACUCCUUCAGCGCGCUGCCUGCCUGCCCAGGGCCUUCCCGGAGAGCAGGUGACGGCGGCCUCCGGGCAUGGAGCUCGCGCUGACGAAAGGUUCUGGAAGCCGCCGUAAAAAGUAAUCAAGAAACGGGUGACAGGACUUUUCGAACAAGGUCUCACCAUGCUGCCCAAGCUGGUCUGAAAACUCUUGUCCUCAGGCAGUCCUCCCACCUCGGCCUCCCAAAGAUCUGAGAUUACAGGCAUGAGCCACCACACCUGGCCUUGGUUUUAAUUCCUGUCACAGUAUAUUAGUUUUCGCUGUUGUGUAUUGAUUGAUUGAGACAGGGUCUCGCUCUGUUGCCCAGGCUGGAGUGCAGGGGCAUGAUCCCAGCUCACUGCAACCUCCACCUCUUGGAUUCAAGUGAUUCUCCCGUCUCAGCCUCCCGAGUAACAGGAACCACAGGUGUGUGCCAGCACGCCUGGCUAAUUUUUUUUUUUUUUUUCUUGAGGUGGAGUUUCACUGUUGUUGCCCAGGUUGGAGUGCAGUGGCACAAUCUCAGCUCACUGCAACCUCUGCCUCCUGGGUUCAAGUGAUUCUCCUGCUUCAGCCUCACGAGUUGUUGGGAUUACAGGCGCCCGCCACCACGCCCAGGUAAUUUUUGUUUAGUAGAGACGGGGUUUCACCAUGUUGGCCUGGCUGGUCUCGAACUCCUGACCUCAGGUGAUCCACCCACCUCGGCCUCCCAAAGUUGUGGGAUUGCAGGCGUGAGCCACUGCGCCUGGCCUAAUUUUUCAAUUUUUUGGUGGAGAUAGGGUUUCACCAUGUUGGCCAGGCUGGAGUUUUGCCUGUUCUAGAAGCUUGUAUCAGUCAUACAACACCCCUUUGAGGAACCGUUUGAGGUGUGGCACGAUACAGCAAGUCAGCUGCCAAAGAGGGGCUUAGCCACAGGAAGUGCGUGCCCAGAACGGUAAAGGGGCUGUGGCCUUUCUUAUCAUCUCCACUCCCUGUCCCCCCCAUCACCUGCUCUUCGUGCUUUGUGAUAAUUCAGUGAGCUCAUACUCAUGACCUGUGUCCUCCAGCAUCUCCCGUGUCCCUCACAGCAGUUCUAUGAGGCUGGCUGCCCUGUUUGACAACUGAGGCCCGCAUCUUCCCCGGAAUCACCGACGUGUGGCUCUGAGCCCUGUCCCAGGGAUUUUCUCCAUCAGAGAAGAGGAGCACUUUGAGCUUUGAGAGGAGCAGCCCUCUGCAAGUGAAGUGGAAAAAAAGGAAGCAGGCGAGGAGGCCCAUCCAGACCCUCCCCCAAGACCCUUGCUGAAAUGGCUGGGAUGCGGCGUGCAGAAGCUCUCCUUUCCUUCACAGCCCCUGGCUUUCCAAGAGUCCCUGCCCACCCAGAUGCCCGCUGGCAGAUGCAGCCUCAUCUCAAGGACACUGCUUGCUGGAUAAAUCCCUCACCACCCUAGAGACAGCCCACGGUCCUGAGACAAGGAUGCGGGCCAGGCUUGUUGCACGUAAGCGCCUCCCGCAGAAACCAGUGAGGCCGGAGUUCCAGAGGAAAUGAUGUAGGGACAGAGGCAGAGGGCCUCCAGGAGGCACCAGCCCCAGAGUCUUCCCUAGAAUCAGACUUUAAGCACAAGCAGGGAGGGAAAGCACUUGAGCAGUGCCCGUCCCUGCAUACCUGGCCUCUGCUGGAACCCAUGCAGGGACAGGACACUUCUUUAUCAGCAAUCCUGUUCCUCUCCUGGGCAGCUUCAACCUGAACAUCCUCCUUCACCUUGAGCUAAAAUGGGUUUCUUGUCACCCUUGCCCAUCAAACCUGGCCUUGCCCUCAGGAACCACACAGGACAAGCCUAAUACUUCCUUCUUGUGGCAACACUUUAGCAAUUGAGACCUGGCUGUCAGGUCCUCCAAAUAAACAUUUGUGACUGUGAUGUUGACUUGCCGCUUCUGGGGACCUCUUCUCAUUUGAUCGGAGAAAGUUUUUCAGGGUUAAACCUACUUCUUUCCCCCAAGAAACUCUUCUUGUCAGGCUCACGCCUAUAAUCCUGGCACUUUGGGAGGCCAAGGCAGGAGGAUUGUUUGAGACCAGCCUGGGCAACGUAGGUAGACUAUGUUGCU

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Publications