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MIR143: MIR143 is a microRNA that has been studied in the context of obesity and ovarian function [PMC9687157]. In a study, it was found that the levels of MIR143 were negatively correlated with the mRNA levels of inflammatory cytokines IL1β, IL6, and TNFα in the ovaries of obese individuals [PMC9687157]. This suggests that MIR143 may play a role in regulating inflammation in obese individuals. Additionally, over-expression of MIR143 led to decreased expression of predicted target proteins HK2 and ADRB1, as well as a reduced Bcl-2/Bax ratio [PMC5735881]. This indicates that MIR143 may also be involved in regulating cellular metabolism and apoptosis. These findings highlight the potential importance of MIR143 in obesity-related ovarian dysfunction and provide insights into its molecular mechanisms [PMC9687157] [PMC5735881]. Further research is needed to fully understand the role of MIR143 in these processes and its potential as a therapeutic target for obesity-related disorders [PMC9687157] [PMC5735881].
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