v22

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Homo sapiens (human) microRNA hsa-mir-127 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-127 precursor URS0000007340_9606

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MIR127: MIR127 is a microRNA that functions as a repressor for RTL1 expression through the RNAi mechanism [PMC3469456]. The expression of RTL1 is significantly elevated in mice with the targeted deletion of the maternally derived IG-DMR, similar to the elevation observed in mice with increased RTL1 expression due to MIR127 repression [PMC3469456]. The increased expression of RTL1 is attributed to the repressor function of MIR127, which is encoded by RTL1as [PMC3469456]. It has been suggested that MIR127, along with other microRNAs such as miR433, regulates the expression of RTL1 through RNAi mechanism [PMC3469456]. Additionally, it has been proposed that DIO3, a gene involved in thyroid hormone metabolism, may not be solely expressed from the paternally inherited allele and may undergo partial imprinting or complete imprinting escape [PMC3469456]. Furthermore, MIR127 has been found to regulate IL-6 and TNF-α cytokine release by macrophages in lung inflammation by targeting IgG FcγRI (CD64) [PMC5247697]. Overall, MIR127 plays a crucial role in regulating gene expression and cytokine release through its repressor function.

Genome locations

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    Gene Ontology annotations

    Sequence

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    UGUGAUCACUGUCUCCAGCCUGCUGAAGCUCAGAGGGCUCUGAUUCAGAAAGAUCAUCGGAUCCGUCUGAGCUUGGCUGGUCGGAAGUCUCAUCAUC

    Taxonomic tree

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    This sequence is found in 39 other species

    1. Ailuropoda melanoleuca microRNA mir-127
    2. Aotus nancymaae (Ma's night monkey) miRNA (ENSANAG00000010944.1)
    3. Ateles geoffroyi microRNA age-mir-127 precursor
    4. Callithrix jacchus miRNA (ENSCJAG00000026365.3)
    5. Canis lupus familiaris (dog) microRNA mir-127
    6. Carlito syrichta (Philippine tarsier) miRNA (ENSTSYG00000021301.2)
    7. Cavia porcellus (Domestic guinea pig) microRNA mir-127
    8. Chlorocebus sabaeus microRNA mir-127
    9. Colobus angolensis palliatus miRNA (ENSCANG00000003328.1)
    10. Dipodomys ordii microRNA mir-127
    11. Equus caballus microRNA mir-127
    12. Felis catus (domestic cat) microRNA mir-127
    13. Fukomys damarensis (Damara mole-rat) microRNA mir-127
    14. Gorilla gorilla gorilla microRNA 127 (ENSGGOG00000031077.2)
    15. Gorilla gorilla (western gorilla) microRNA mir-127
    16. Heterocephalus glaber microRNA mir-127
    17. Lagothrix lagotricha microRNA lla-mir-127 precursor
    18. Marmota monax (woodchuck) non-coding RNA
    19. Mustela putorius furo (Domestic ferret) microRNA 127 (ENSMPUG00000023457.1)
    20. Myotis brandtii microRNA mir-127
    21. Myotis davidii microRNA mir-127
    22. Myotis lucifugus microRNA 127 (ENSMLUG00000017857.1)
    23. Nomascus leucogenys miRNA MIR127 (ENSNLEG00000021779.2)
    24. Pan paniscus miRNA MIR127 (ENSPPAG00000013220.1)
    25. Panthera pardus miRNA (ENSPPRG00000013652.1)
    26. Panthera tigris altaica (Tiger) miRNA (ENSPTIG00000003174.1)
    27. Pan troglodytes microRNA ptr-mir-127 precursor
    28. Peromyscus maniculatus bairdii microRNA 127 (ENSPEMG00000006052.2)
    29. Pongo abelii microRNA mir-127
    30. Pongo pygmaeus microRNA ppy-mir-127 precursor
    31. Pteropus alecto (black flying fox) microRNA mir-127
    32. Pteropus vampyrus (large flying fox) microRNA 127 (ENSPVAG00000024956.1)
    33. Rhinolophus ferrumequinum microRNA 127 (ENSRFEG00010005252.1)
    34. Rhinopithecus bieti (Black snub-nosed monkey) miRNA (ENSRBIG00000018257.1)
    35. Rhinopithecus roxellana miRNA (ENSRROG00000027377.1)
    36. Saguinus labiatus microRNA sla-mir-127 precursor
    37. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) miRNA (ENSSBOG00000003979.1)
    38. Ictidomys tridecemlineatus microRNA mir-127
    39. Suricata suricatta microRNA 127 (ENSSSUG00005012097.1)
    40. Cebus imitator None
     2D structure Publications