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Homo sapiens (human) microRNA hsa-mir-127 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-127 precursor URS0000007340_9606

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MIR127: MIR127 is a microRNA that functions as a repressor for RTL1 expression through the RNAi mechanism [PMC3469456]. The expression of RTL1 is significantly elevated in mice with the targeted deletion of the maternally derived IG-DMR, similar to the elevation observed in mice with increased RTL1 expression due to MIR127 repression [PMC3469456]. The increased expression of RTL1 is attributed to the repressor function of MIR127, which is encoded by RTL1as [PMC3469456]. It has been suggested that MIR127, along with other microRNAs such as miR433, regulates the expression of RTL1 through RNAi mechanism [PMC3469456]. Additionally, it has been proposed that DIO3, a gene involved in thyroid hormone metabolism, may not be solely expressed from the paternally inherited allele and may undergo partial imprinting or complete imprinting escape [PMC3469456]. Furthermore, MIR127 has been found to regulate IL-6 and TNF-α cytokine release by macrophages in lung inflammation by targeting IgG FcγRI (CD64) [PMC5247697]. Overall, MIR127 plays a crucial role in regulating gene expression and cytokine release through its repressor function.

Genome locations

Gene Ontology annotations


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This sequence is found in 40 other species

  1. Ailuropoda melanoleuca microRNA mir-127
  2. Aotus nancymaae miRNA (ENSANAG00000010944.1)
  3. Ateles geoffroyi (black-handed spider monkey) microRNA age-mir-127 precursor
  4. Callithrix jacchus miRNA (ENSCJAG00000026365.3)
  5. Canis lupus familiaris (dog) microRNA mir-127
  6. Carlito syrichta (Philippine tarsier) miRNA (ENSTSYG00000021301.2)
  7. Cavia porcellus (Domestic guinea pig) microRNA mir-127
  8. Cebus imitator microRNA 127 (ENSCCAG00000015850.1)
  9. Chlorocebus sabaeus microRNA mir-127
  10. Colobus angolensis palliatus (Angola colobus) miRNA (ENSCANG00000003328.1)
  11. Dipodomys ordii (Ord's kangaroo rat) microRNA mir-127
  12. Equus caballus (horse) microRNA mir-127
  13. Felis catus (domestic cat) microRNA mir-127
  14. Fukomys damarensis microRNA mir-127
  15. Gorilla gorilla gorilla microRNA 127 (ENSGGOG00000031077.2)
  16. Gorilla gorilla (western gorilla) microRNA mir-127
  17. Heterocephalus glaber microRNA 127 (ENSHGLG00000022131.2, ENSHGLG00100024164.2)
  18. Lagothrix lagotricha microRNA lla-mir-127 precursor
  19. Marmota monax non-coding RNA
  20. Mustela putorius furo microRNA 127 (ENSMPUG00000023457.1)
  21. Myotis brandtii microRNA mir-127
  22. Myotis davidii microRNA mir-127
  23. Myotis lucifugus microRNA 127 (ENSMLUG00000017857.1)
  24. Nomascus leucogenys microRNA 127 (ENSNLEG00000021779.2)
  25. Pan paniscus microRNA 127 (ENSPPAG00000013220.1)
  26. Panthera pardus (leopard) microRNA 127 (ENSPPRG00000013652.1)
  27. Panthera tigris altaica microRNA 127 (ENSPTIG00000003174.1)
  28. Pan troglodytes microRNA ptr-mir-127 precursor
  29. Peromyscus maniculatus bairdii (Northern American deer mouse) microRNA 127 (ENSPEMG00000006052.2)
  30. Pongo abelii microRNA mir-127
  31. Pongo pygmaeus (Bornean orangutan) microRNA ppy-mir-127 precursor
  32. Pteropus alecto (black flying fox) microRNA mir-127
  33. Pteropus vampyrus microRNA 127 (ENSPVAG00000024956.1)
  34. Rhinolophus ferrumequinum (greater horseshoe bat) microRNA 127 (ENSRFEG00010005252.1)
  35. Rhinopithecus bieti (Black snub-nosed monkey) miRNA (ENSRBIG00000018257.1)
  36. Rhinopithecus roxellana miRNA (ENSRROG00000027377.1)
  37. Saguinus labiatus microRNA sla-mir-127 precursor
  38. Saimiri boliviensis boliviensis miRNA (ENSSBOG00000003979.1)
  39. Ictidomys tridecemlineatus microRNA mir-127
  40. Suricata suricatta (meerkat) microRNA 127 (ENSSSUG00005012097.1)
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