gga-mir-99a: Gga-mir-99a is a microRNA that has been studied in various contexts, including its effects in MG-mediated inflammation in chickens [PMC5979595]. It has been found that several other microRNAs, such as gga-miR-18, gga-miR-193a, gga-miR-193b, and gga-miR-30b, are differentially expressed in chicken lungs infected with avian influenza virus [PMC5389138]. In other studies, miRNAs such as miR-574-3p and miR-30a were found to be differentially expressed in cells infected with influenza A virus [PMC5389138]. Gga-mir-99a has been shown to target the SMARCA5 gene and regulate Mycoplasma gallisepticum infection by suppressing cell proliferation in chickens [PMC6663980]. It has also been observed that gga-mir-99a is down-regulated in MG-infected lungs of specific pathogen-free chicken embryos [PMC6663980]. Additionally, gga-mir-99a is one of the miRNAs predicted to target SREBP-1c and is up-regulated in the liver of leptin-treated chickens [PMC3436634]. Gga-mir-99a has also been detected as enhanced in response to M. gallisepticum infection and its over-expression leads to a decrease in cell proliferation [PMC7238135]. Overall, studies have shown that gga-mir-99a plays important roles in various infections and may have potential therapeutic implications for diseases such as chronic respiratory disease (CRD) caused by Mycoplasma gallisepticum infection [PMC6121889][PMC6562429][PMC7734234].