ame-mir-279a: Ame-mir-279a is a microRNA that has been found to play a role in regulating honey bee division of labor. It is highly expressed in the heads of nurse bees compared to forager bees, and its overexpression decreases the proboscis extension response (PER) to saccharose solution, while its knockdown enhances workers' PER [PMC9863880]. Ame-mir-279a is primarily localized in the Kenyon cells of the mushroom body in both foragers and nurses, and its overexpression enhances the proboscis extension response to sucrose solution, while its knockdown diminishes this response [PMC10058195]. It has been observed that ame-mir-279a shows significantly higher expression in the brains of nurse bees compared to forager bees regardless of their ages [PMC7073825]. Furthermore, ame-mir-279a directly targets the mRNA of Mblk-1 [PMC7073825]. This microRNA has been implicated in regulating honey bee division of labor, as it is highly expressed in nurse bee heads compared to foragers [PMC7073825]. These findings highlight the important role that ame-mir-279a plays in regulating honey bee behavior and division of labor.