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Homo sapiens (human) ZNF706 neighboring transcript 1 (ZNNT1) URS000194B0FA_9606

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ZNNT1: ZNNT1 is a long noncoding RNA (lncRNA) that has been implicated in the regulation of autophagy and the inhibition of tumorigenesis in uveal melanoma (UM) [PMC9870980] [PMC9876672] [PMC9393691] [PMC8392202]. Abnormal expression of ZNNT1, along with other lncRNAs, has been associated with the development and progression of UM [PMC9876672]. ZNNT1 promotes autophagy in UM by upregulating the expression of autophagy-related gene 12 (ATG12) and modulating the ATG12-ATG15 conjunction [PMC8392202]. Overexpression of ZNNT1 has been shown to induce autophagy and inhibit UM tumor cell growth and migration, while its knockdown represses autophagy induced by certain stimuli [PMC8735716] [PMC10000689]. ZNNT1 is downregulated in UM tissues and its overexpression leads to increased cell death, impaired migration, and inhibition of tumor growth both in vitro and in vivo [PMC9913768]. Furthermore, ZNNT1 acts as a downstream effector of MTOR signaling pathway to promote ATG12 transcription, induce cell death, and suppress UM tumorigenesis [PMC8978265]. Overall, lncRNA ZNNT1 shows potential as a tumor suppressor in UM through its regulation of autophagy-related genes such as ATG12.

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Gene Ontology annotations

Sequence

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CCCCAUCUCUACUAAAAAUACAAAAUUAGGCAGACAUGGUGGCACGUGCUUGUAAUCCCACCUACUUGGGAGGCUAAGGCAGGAGAAUCGCUUGAGCCCGGGAAGCUGAGGUUGUGGUGAGCCAAGAUCGCUUCAUUGCACUCUAGCCUGGACAACAAGAGCGAAACUCCGUCUCAAAAAGAAAAAAAAAAUUGGCCCCACUCAAAAUGGUACUCCUCCAAGUUGCUUUUUCAUCCUUGUAUUCCCCAUGGUCAUUCAUCCCACUGCUGUCCUUCUGUCUCCAAGUCCUCUUUGCCUUGCUUCCUUCCCUCUCAACCCACAGCAUCAGAGCAGUUUCUCCCCCAGCUGACCCUCUUUCCACUUUCAGUGCUCAAUAUUUUUUACUUUGCCUGUGGAAAUGAUCUCUUAACUGGUUUCCUUAAGUCCCUCCAGAAAUGUUUUUCUAAACUCCAACAACUGUGCAAGGUCUAAUUGCCAUUGGUUUAUCACCCACUGGACCCAGAAGCACCAUCCUGGAUUCUGCUUCUGCAUACCCCUGUCAGCUCUGUGUCUUUAGGGACAUCAUUUAAACCUUCAGCUUCACUUUCUCCACUUAUAGAAUGAAGAUGAGGAACAAGAACAUCAAUCUUUGAAAUGAUGCCAAGUAUAAGCCUCUGUGUGUGUGUCUCCCCACUCCAAUUUGUCCAACAGACUGCUUCCAAAGAAAUCUUCCUAAAACACUGACCAUCUUUUUUUUUUUUUUUUUUGGCUGCAAAAUCUUUCAUUUCCUCAUCCCCUCACAUAACUUCCAAUCUUCUUGGCCUGGCACUAAGGACCUACUACAGACUGGCACUGAAAUAUCUUCCCUACCUUAUCAUUCCUUGUGCUUCUCCACAAGCCCACUCUUCCCCUUCAUCAUACAUGUGCCGACCUUUCCUGUCUCUUUUACUUUGCAGCACCAAAUGCUUUCUACUUUGUGGUCUAGGAGGAACACAUGUCACUUUUGUAAGCUGCUCGAAAGCAGGGGCCACACCUUCAUCCUUGUUUUCCACACAACACCAAGCACUUAGUAGACACCCAAUAAAUCAUUGCUGAAUGAAUGUAUUCAGCCUGGAAUUGCACUAGGAUUUUUUGGCCAACACAUUGUAUUCUUAACUGAUACCAGACUUCCAAUCAAAUAAAAUCCUUAAGCCUUUUUCAUAGUCUUUAAUUAAACUACUUCUCUUCCAUUAUUUCCCUUUGCCUACUUUUGAACUGAUAUUCAGAACUUUUCUGUUAAUGUUUAAUUUUCAUCCAUUAUUCUUGUCUGUACAGAUCUUUUUGAUUUUUGACUCUCUUAUCUAGUUUUUUUUUUUUUUUUUUGGCUUCCCGUUGUGUUAUCCACAGGCACAAUGGGUAUAUUGACUAUCGUUCAUUGAAGUUGUUGAUACAAAUGUUGAACAGGAGAAAAACCAGUAGCUUGCCAACUUGGCACCUCAUUCUCUAGCUUGACAGUAAUCUCUUAUCUAGUAGUUUUUAGAUAUGGUUAUUUAAUCAAAUAUCACUAGCUUCUAAUUUUGUUAUAAUUCAUUCAUGUAUACAGACAAUGAAGAAUCAUCUUUCUUCAUUCAACACAUUUAUUGGGAACCAAUCAUUGUCCAAGGCAAUAUGCUAGGCAUUGUGUAAUAGAAAGCGAUUAAGCUUUUACCCCUGUCCUCUUUGGCCUGCAAAGAGCAGGUAAGAUUCAUGCACAGACAAAUGUAGUACCAGGUAAAUAGUGAGGCCAAACACAAGAGGCAGGUCAAAGGGCUUUGGAUUCAGAGGAUGGAGAAGCUCUUUCUAGGCUGGUGAAAUAUUUGCAGAAUGAGUAGGCUCAUAAGUGGAGGUGAGGUACAGGCUAAGCUGCUGUAAGAAAGAGUCCAAAAUGCAAAGGAUUUACCACAAUGCAGUUAAUUUUUCUCACAACGGUCGAGGUAGGCAGGUGGUCCAAGUCCAGUUAAUCAGCCCUCCUCAACACAAGGCUUCCCCUUGUAAGCUCAGGAUGACCGCUCCAGUUCUCAUCAUCUCCCAGGCAGAAAAACGGGAGAAAGAGAACUAGACGUACCACCCAGUCAUUUUAAGGACAUAGCCAGGCCAGGUGCAGUGACUCACAUCUGUAAUCCAAGCACUUUGGGAGGUCGAGGCUGGAGGAUAGCUUGAAGCCAGGAGUUUGAGACCAGCUUGGAUAAGAAAGCAAGACCUUGUCUCUACAAAAAAUUUAAAAAUUAACCAUGUGUGGUGGUGUGCACCUAUAGUCCCAGCUACUCAGGAGGCUGAGGUGGAAGGAUCACUUGAGCACAGGAGUUGGAGGAUACAGUGAGCCAUGAUCACACCACCUCACUCCAGCCUGGGCAACAUAGUGAGACCCCAUCUCUUUAAAAAACAAAACAAAAAAACAUCACCAGGAAGUUGCUUACAUGUCUUCUAUUCCUAUAACAUCGGCCUGAGCUUAGUCACAUGGCCACACCCAGCAGAAAGAACUCUAGGAAAUAUGGUCUUAUGCUAGGUAACCCCAAACCCAGCUAAAACUGUUGCUUUUGAAGAAGGGUGAAACAGACAAUGUGGAGGAGAAUUACCAGUCUGCCACAAAGAGAAAGAAUUCUAUGUGAGGAAAACGCUCUAGAAGAGGGAGCUGAUUAAUUAGUUAUAUCUCAGCCGAGAGGAUGUUAUGAGAAACACAGAUUUGGGUUUAAUAGAAAAACUUAGAACCCUUCAAGAAGGAAUGGGCGGACUUGAGAGUGUCCUCCGCUUCUGAAAAUGAUCAAGAAAAAUGGUAAGAAUGUACACCUCAAGGGUGGAUGGUAAAGGUCAGCCUUUAAGCCUCAAUGGCGGUGUGGUUGUAGGUGGGGUGGGGGUGGAGGCCCCGAAGACAGGCAGACUACCACAGUAGCCCCGAUGGAAGCAGUGAGAAUGAACUGGAAGGAGCGGCUGUGGGAGCGACAACGUGAUGAGAAUAAACCCGGCUUGGCUCUGCCCUGUGCACACACAGGUGAGCUGUGUGCUCCCGGAUGUGUCAGCUGGUAUAUGCGUCUGUCAGAAGGCAGCUGGGGAGCACUGUUAGCUCAGAGACUAAGAGGCAGACCCAGGAAGCCCUUCUUUGCAUUGGUCAGGGUUUGCUGCAUUUUCCCAAGCCCAGGAAAUGGAACCCAGUUCUUCUUCUUUCUGUGUAAAAUAAUAAGCAUCACAAUAGGCUGUGCUCAUGAGAACGCAUUUUGUUUCCACAGAAAUGUUUUUUCUCACUCUGUCCUGAUUUUGAUUUCUGUUAAACUCAGUAAACACAUUACCAAAUUUUAAAAUAAGGUGACUUGUUUUCCCCAACUCACAGUUCACCAAAGGUAUUUCAUCUGUUUGUUCUGAAAAUGCAGCUGCUGUCUAGAUUUAUGUGUGCUCUGACAAGAAAUGUUUUGUGUAACAAUAAAAAUCAUUUCCUUUGAUGAA

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