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hsa-mir-770: Hsa-mir-770 is a microRNA that has been found to be significantly upregulated in urine and blood samples from patients with diabetic nephropathy (DN) [PMC9266798]. The hsa-mir-770 precursor expression vector, named miR-770, was constructed with synthetic oligonucleotides and incorporated into a plasmid [PMC6276177]. In breast cancer, hsa-mir-770 is one of the 10 miRNAs that are significantly downregulated compared to normal tissues in patients with good prognosis [PMC8004706]. In another study, hsa-mir-770 was found to be lower in MMVP specimens compared to FED samples [PMC4881574]. Additionally, hsa-mir-770 has been identified as one of the most downregulated miRNAs in various cellular conditions such as testicular germ cell, embryonal carcinoma cell, and hippocampus cell [PMC7820843]. Overall, these findings suggest that hsa-mir-770 may play a role in the pathogenesis of DN and breast cancer prognosis. Further research is needed to fully understand the functional significance of hsa-mir-770 in these conditions.
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