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Homo sapiens (human) deleted in lymphocytic leukemia 2 (DLEU2) URS0000EF28B1_9606

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DLEU2: DLEU2 is a gene that has been studied in various types of cancer. In thyroid cancer cells, depletion of DLEU2 has been shown to significantly suppress cell proliferation [PMC8111323]. In prostate cancer, it has been demonstrated that E2F2 contributes to the overexpression of DLEU2 [PMC8786838]. Additionally, in a study involving the BL strain, it was found that Sphk2, a negative regulator of inflammatory macrophage activation, is among the genes induced by this strain [PMC8265813]. Furthermore, it has been suggested that EZH2 may facilitate HBx binding to DLEU2 sites that are not bound when HBx is alone [PMC7569396]. Finally, inhibition of PIK3CD was found to abolish the role of DLEU2 in promoting cell vitality, proliferation, and colony formation [PMC7303144]. DLEU2 is a long non-coding RNA gene that has been implicated in various cancer types. It plays a role in cell proliferation and vitality and its overexpression has been observed in thyroid and prostate cancers. Additionally, its interaction with other genes and proteins such as E2F2 and EZH2 may contribute to its dysregulation. Furthermore, inhibition of PIK3CD can counteract the effects of DLEU2 on cell behavior. These findings highlight the importance of understanding the role of DLEU2 in cancer progression and suggest potential therapeutic targets for intervention. References: - [PMC8111323] - [PMC8786838] - [PMC8265813] - [PMC7569396] - [PMC7303144]

Genome locations

Gene Ontology annotations

Sequence

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UGGGAUUGCAGGGGUAAGCCACCGCGCCCCGCCGCAACAAUGACUUUUUUAAAAAACAGGCAUUUACUGCAUUUUCGUACACUAGAAGCUAAAAUACCAUGCUGUCCAGUUCAAAACAGGACACCUGGCAACCCUGUUCCUAACAGCUUUCUGCAAAGCCAACACCCAGUGCUUUCUGGCUGCAUUGGCCUGUCCUCAUUUCCCCCUGGAAAACUUGUUUUAAACAGUACAGAUAACAUUCUGCCUCUAUUACAAUUAGCAGCUUCUCUCACCAGGUUAUCUAGUGUGGCAAGUGCUAGUGCGGAGUCACUUAGUAUCUUCUUUCAAAACCUCCCAGUGGCUGCCUUCAGGUAGCAUGUGAAAAGCUGCUCAUGGGGAAUUCAGCAGCUGCUUCAGGCCCUCCAGGGCAUUUCUUGCUGGCAUCUUCUGCCUCACCAGAUCGCCCUGAUUAUUAGUGAUCUGGGCCCCCUACCUAAUGGAAAACCAGCCACUCUUCUUCCCAGCCCCAAUGGAUAUUGAUGAGGGGUCCUUAAAUCUGGGAUCCUUUCCCCUCCUUGCCCAAUAAUUGAACUCCUAAAAUCCUUUUACUACCUGGGAAUCUGCAAAGACAACCUUGAAUUUGAACUGGAGCUAGAAGGACUUCCUCCGAACGAAUUUGCCCAUAGAUGACUCUCUGGUACAUGGUCUCUGUUGUUCAACUUUCUCUAUUCUGAAGUCUAGAAGACACCCUUGCUUCUGAAAGUGGGGCCUAAGAACCUGCAGCCUCACCAGGGAGCUUGGUAGAAAUCCAGAAUCUGAGGCAGGAUUCUAGACUUAUUGGAUCAGAUUCUGCAUUUCAACAAGAUUCCCCAGUGACCCCCAGGCAUCUUCAAAUUUGAGAGGCCAGGAAAGUGCUCAGGCCCUGCCCUUCCCUUCCCGUUGGCUGGGGAGAAUUCCUGUAAUUUGCCCUGUUUACGGGUCCUUAAUCUCCAACUUCACUGUCCUCGCUUUCCAAAGAAUCCUGAGUGGCUUCCUUCCAACACCUUAUCUGUCUUCCCCCACGCCCCUGAAGCCAGGGCCUCUUUUCUUCAAGGCCACCCCCCAACUCAUCUCAGGCUGAGGCUCCUCUCUUGAGGCCAUAUCCCAUGGUAGCAUUUCUUUGAGGGCUGCUUUUCUGCCGUUUUUCUCCCCAGGUAGGGCCUCUAAAACCGAUGGAAGUGAAGUGCUACACCUCAGAGCUGCUUUAGCCCUUAGAGCUGGCCAGGGUCUGAGUGGGCCUCUCACAGGGCCACAGGACUGCCCUUUCCCCCAGCAUGCCUAGAAGCUGAGACCACUCACACCACAUGAACAUGCUAUCCUUGUUCCUCUUUCCUGCCAGCCUCAACACAACCAGAAUACAGCCCAAUAAUGGCUGCCUACAAAUGGGAGGCACCCAGGGAAGGGAGGGGGUGCUGAUUAAGAACCAGCCUGGAGGAGGAUCAUGGUUUCUCUGAAACAAGAAGGAGAAACAGAUGCCCUGCCCAGAAGCAACACGGCUAAUGGGUGCCACCGUGGAGACCCAGGCAACCUGAGAGUAGUCCUGACAGCCAGACCUCCAGGGUGGAAAUGGGAAGGUCUACAGAGAAAGGUCAGGAUUUAACAGGGAAAUGGAGGAGGGCAAGAAUGGGGGUCAGGAGGUAUCUACGCAUUUUGAUAUGAAAUUAAGAAGUUCAUUUAAAAUAUACAACCAAGGCCCGUGACACUUUUUGUAACAAGAUUCUAGCUUAUCUUCCCACUAGAUUUUGUUGGACUUUUUUCAAAUUGUAUCUGAUUGUGUUUUUCAAACUAGGCCAGGAGGGCCCCUCAACUUCUAAAAUACAAAAAUUCUUUCUGCUCCUCUUUUCAAAUCUUCUCAGAUUCUGGACACACCCAGAAAUUCCAUGUGCCUUUUUACUCCCUUAAUCCUGUUAACUUUUUGUCUCUUCUUAGCAAUGACUUCCUUUCAUUUUAGAGAAAGUUCUGCUGGUAACAUACUGUAUAAGCCAGGAGAGAAAAAGAACUUGAAAGAGGAACACAUUUUUCUUCAUUUUUUUUUUUUCAAAAAAGGUAAGGGAAAAAAAUAAAGGAAGUGGAGAAAUAUACUACUCAGUACAGUUGUCAAACAAAUUUCUUGGAACCAUGGCCUACAAGAAUACCUAUCUUAACUGCAUUGCACUAGAAACCACAUUUUCAUAUUCCUUUUGUGAUAAUUCUAAGAUAAUGAAUUAGAUGUUAGCCAUUGUUUUCCAGAAUAGAAUUUCUGGAGUUACUGGUAGUUCAGGGAAUUUUAGUCACAAGAUAUAUAUUUUCUGUACCUUUGUGUGUGUGUAUAUGUGUGUAUGCAUAUAUACUUAUAUACAUGCACAUAUAUACACAUACACACAAACAUGCAUGUGCUAUAGCUUUUGAAUGGAGAUAUAUGUGUGUGUACACACACACACAUUCAUUCAUUCAUUUAUAUCAUACAGCUUCUCUGAAGAGCAACAGGAGAAAAAUGCAGGAAAUAUAAAGGCAACCUGGGGUCAGUCCUAUGCAGUGAGCUCUUUGAGGUCUCCAUCAGAAAUAAAAGAUUUCAGUCUUUUUUGGCUGGGCACAGUGGCUCACACCUGUAAUCCUAACACCUUGGGAGGCCAAGGUGGGAGGAUUAACAAAAAAUACAAAAAUUAGCCGGGGGUGGUGGUGGGAGCCUGUAGUCCCAGCUACUUGGGAGGCUAAGAUGGUAGGAUCACCUGAGCCAGGGAGAUGGAGGCUGCGGUGAGCCAUGAUCGCACCACUGCACACCAGCCUGGGUGACAGAGUGAGACCCUGUCCUAAAAAAAAAAAAAAAAAAAAAUCAAUCUUUUCAUAGUUAUUCAAAUUAAAACAACAAAAUAGAGAUGUGAAGACUUGGCUCAGGAAGAUUCAGUCAUCUCAACAGUCACUGUAAAGAACUGCCAUCAGACUCCUUUUGACUCUAAAUGGCAAAGGAUACCAACACUGUUCUUCCUAGGAAGCUAAUCUAUAGUUAAAAUAGGCACAUUGCAUAGCUCUGUGUAUCUACAGUGUUGUAAUUGUCUAACAGAGUGGAGAUACUAAAUGUACUCAGUGCAUAAAACACAUUUUAUUUAAAAUAGAGAGGAAAUUCCUGAGGGAACAAUAAAAUCAAGGAUGUUACAGUAAUUUCAUGAGC

Taxonomic tree

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