SNHG6: SNHG6 is a long non-coding RNA (lncRNA) that has been found to have various functions in different types of cancer. It has been reported to act as an epigenetic modulator in chondrosarcoma, mediating the association between histone methyltransferase and target genes [PMC7801621]. SNHG6 has also been implicated in atherosclerosis prevention [PMC6947907]. In melanoma, SNHG6 expression is significantly upregulated [PMC7583849]. It has also been found to regulate gemcitabine resistance in pancreatic cancer [PMC9961296]. Knockdown of SNHG6 has been shown to affect the sensitivity of esophageal cancer cells to 5-fluorouracil (5-FU) treatment [PMC10067833]. Additionally, SNHG6 can directly bind to EZH2 and regulate the expression of p27, a protein involved in cell cycle regulation [PMC9734177]. SNHG6 can act as an oncogenic factor or a tumor suppressor depending on the type of cancer. It can activate JNK or TGF-β/Smad signaling pathways to promote tumor cell progression, or suppress cell proliferation and metastasis by inactivating the PI3K/AKT/mTOR signaling pathway [PMC7180593]. SNHG6 has also been implicated in various other cancers such as glioma, colorectal cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma, gastric cancer, non-small cell lung cancer (NSCLC), and hepatocellular carcinoma (HCC) [PMC8414414] [PMC7838315] [PMC6448242] [PMC10134332] 33[PMCID7180593] 33[PMCID6714173]. Furthermore, SNHG6 acts as a molecular sponge for several microRNAs (miRNAs) in different cancers, including miR-26a/b, miR-214, miR-195-3p, miR-423-5p, and miR-101-3p [PMC10134332] [PMC9734177] [PMC7412850] [PMC8661508] [PMC6749705]. In conclusion, SNHG6 is a versatile lncRNA that plays a role in various cancers and can have different functions depending on the context. It is involved in multiple signaling pathways and can interact with different molecules to regulate gene expression and cellular processes.