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Homo sapiens (human) rhabdomyosarcoma 2 associated transcript (RMST) URS0000CCE0AF_9606

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RMST: RMST, a long non-coding RNA (lncRNA), has been found to play a crucial role in various biological processes. It has been shown that RMST is induced by BMP9 through Smad signaling during the intermediate early stage of osteogenic differentiation [PMC6949095]. In neurogenesis, the absence of RMST leads to differential expression of over 1000 genes, primarily by facilitating Sox2 binding to promoter regions and regulating target genes [PMC7260844]. Additionally, RMST has been found to be upregulated in ependymoma and interacts with FUS, enhancing its SUMO1 modification [PMC8196486] [PMC7019048]. In relation to cancer, high expression of RMST is associated with high survival rates in Wilms tumor patients [PMC6915924], but its role in prostate cancer remains unknown [PMC4633711]. Furthermore, RMST has been shown to activate microglial cells through TAK1-mediated NF-κB signaling and regulate the SOX9 protein [PMC8936393] [PMC8825559]. In cardiovascular diseases, both RMST and miR-244-3p are actively involved in their occurrence and regulation [PMC8974166]. Additionally, the regulation of RMST expression in endothelial cells (ECs) and its role in mediating EC survival, proliferation, migration, and differentiation are being investigated [PMC8567064]. Furthermore, RMST interacts with SOX2 to co-regulate downstream genes implicated in neurogenesis such as DLX1, HEY2, and SP8 [PMC5491930]. Finally, inverse probability-weighted restricted mean survival time (RMST) is being used as a measure for all-cause mortality during ART initiation studies without competing events present  [PMC5845164] [PMC8986535].

Genome locations

Gene Ontology annotations

Sequence

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AUUUCAUUUGUGAUUCGGAUGAUGCAGCUCUAGGUGGAUUGACUAUGAAAGGCGCUGAAUAUCUUCAGGAAAAUGGGUUCCAUGAGAAGUGACAUCCUCCUCGAAUCAAAAGAUUCUCAGGAUGAUGGAGUGAGUGAUGGAAUAGGUUGCCAACUGUAGUUACUCCACUCAGCACAGAAUGGCUGCGGGGAAAUAUAAUCAGACAUGCCCAAAGAAGUCUGCUUAGGGUGAAACAAAUACCUUUGAGGUUUAAAUCAGGAAGGAGAGACUGUUUCUACAGGUGUCAUACAAAAAUCAAUACUGAGCCAAGGAUUAUUGGAUCCCAUAGAACCACGGAGACUUGGUAGUGAAAUUCUUCCAAAGCAUUCCAUCCGUGCAGGCAGAUGGUGUUCCUAGGUUUGGAAAUAUAAAUCCCAUGGGAAGUCAGCUGAAGACCAUUUUAUGCAUCACUCAUCCUGUUAGAGCCCUGUGCUGUUCUGUCUCUCUAUAAGACUGGCUGAAACCACCACGGUUGUUUACAAUUUAUGCUCUAACUUUGGAUCACCUAGUUAAUACUCUAACUCCGAUUAUUACCAAAGACAAUGUUCUAUAAAAGAUAUUGUCUAUUAGAAGGAUGCUUCUGCAUUAUUAAUAAAAUCACAGGGAAAAUGCAACAUUUUGGAUGUCACAUCUGAUAAGUUGGCAGUUAAAGAACAGAAACAGCAAUAAGACUGCGUGGCUACAUUUUCCCAGUGCCACCAACUGGGAUUUAAGCUGACUAACAUUUUGAAAGCCCAGCCCAUUUCAUUCACAGCAGGAUGGCAGUGGGUGACUGAUCGUACCCGCCAGCUGGCUAAUGUCAUAAUUAACAAAGUUGCUACUACAUCUGCAAAGUUUAAUCGAAAAAUUUGCCAGUGAUAUGAUGGCCUUGUCACAGAGAUCACAAGGGACACGGAGUUGACUUUUGCUCAAGGUGGAACGACAGAGCUGUGUAGGCAAGAUGAGAAAUUGCGAACUUGUUCGGCCAAAGGAUUAUCUCCUGAGAUGUGUAGAAAUGAACUCUUGUCAGAGUUUCAAAGGAAUUAACGUUUUUUGGUAAAAUGUGCUAAUGUAAAGAGUGAGAAGAUUAGUGAUACAUAAUGAAAGCAAUGCAUUCUUUCACAUGGAAAUGGGAAUAUAAUAAAUGUCCUGCAGGUGAUUGGGGCUGUAGCAAUUUUAUUGAAGAUUAAAGUUUGAUUGACCUUUGUUAGGGUGAUUAACCCUUCUGAAAUUAAAAGCCAGAGCUGAAUUAUUCUGCUCAAUUUAAAUGCAAACAUCGAGCAGGUCGUAUGUCAUUCAAAUAAUAAUAAGAAGAAAAUCUUCCUAUUUUAAUUUUCAUUUUUGCACUUCUGAGUGGUAUGCUGCUUUAGAAGGACCAUAGCUCUCGCAAAAGCAUUCUGGUGGCAGAGAAUAUACAAUAACGUUACAGAUAAUUGGGAGCAUAUAGGAAGAGUCCCAAGCACUACUGCCUGCAUUCGAAACAUCAAAACCACCAUCCCAACAAAAGCACGGAGCAUGAAGCCAAUCUCUGUACACUGAAAAUGCAUGCUCCCAAUAGAAAAACAACCUAGGGAUGUCCUGAAGGGGUUAGGAAUAAAUAACAAUGACAUCUCUAUUCUAGUUCAGUGCCAACCACCGAAAUUGCAUAUCAUAUCCAUGUUAAAUCUACAUGAUGUCUCCUGGAAAUGCGUGCUUUUUGGUACAGUUGCUUAUGAAGCAGUUUCUAAAAGUUGAUUAUUUCUGAUGUCUGGAAUUUCAUUCUCCAUGAUCUCUGGCAGUUUCUGAAUAUAUUCAGUAUUUUCAUUAAGUUCAAAAAUGCUGUAGGAGAAGCUAACGAAUUAUUUGCAAUGCCAUUUAAUGGUUUAGUUUUAUUUUUCUCUGUUAAAUUUUCUAAGCCUUGGUGAAAAGUUGUGUAUUCACAUUUCUUCAAAAAACUGUUUCCAUUUUUCAUAUCAUGUUAAUUUUGUUUAGUUCUAAGUCAGUGAAUAUUUUUAGUCUUAGGUCCCACCACAUAGUGAAUGUGUCUGCCUUUUAUGUAUCUGUGAACUAUUAAAAUGAUAAUAAAGGUUCUCUUCCUUCCAU

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Publications