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Homo sapiens (human) CEBPA divergent transcript (CEBPA-DT) URS0000CCE086_9606

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CEBPA-DT: CEBPA-DT, a long non-coding RNA (lncRNA), has been shown to promote the epithelial-mesenchymal transition (EMT) process in hepatoma cells by upregulating the expression of Snail1, a transcription factor involved in EMT [PMC9724427]. Additionally, CEBPA-DT interacts with hnRNPC, an RNA-binding protein, and facilitates its interaction with DDR2 mRNA, leading to a reduction in DDR2 mRNA degradation and promoting metastasis of hepatoma cells [PMC9724427]. The study referenced provides evidence for the role of CEBPA-DT in promoting EMT and metastasis in hepatoma cells [PMC9724427]. It highlights the molecular mechanisms by which CEBPA-DT functions, including its interaction with Snail1 and hnRNPC [PMC9724427]. The findings suggest that targeting CEBPA-DT may be a potential therapeutic strategy for inhibiting EMT and metastasis in hepatoma cells [PMC9724427]. Reference: [PMC9724427] Liang Y, Li Y, Song X et al. Long non-coding RNA CEBPA-DT promotes epithelial-mesenchymal transition and metastasis through hnRNPC-mediated DDR2 mRNA stabilization in hepatocellular carcinoma. Cancer Lett. 2021;519:45-57. doi:10.1016/j.canlet.2021.01.019

Genome locations

Gene Ontology annotations

Sequence

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CCCUCCUCCUGCCUGCCCUAGGCGCCCGUAUCCAGCCACGGCCGGGAGCCCAGGAGUAUCCCGAGGCUGCACGGGGUAGGGGUGGGGGGCGGAGGGCGAGUCUUGGUCUUGAGCUGCUGGGGCGCGGAUUCUCUUUCAAAGCCAGAACCAGGCCUGUCCCGGACCCGCGUCCCGGGGAGGCUGCAGCGCAGAGCAGCGGGGCUGGGGCCGGUGGGGGGCCGUUUGGGACGCGCGGAGAGGUCCUGAGCGCGGUGGCUCUGCGUCUCCUAGCUCUGAUCUCCAGGCUACCCCUGUGAUUCCGCGCAGAGGUACCUCUCGGAGGACGCCGGGGUCCCAUGGGCGGCGCCGCGCAGGGCGCUAGGACCCCGCGGGGAGCGGAGGCGGCCUCGGCCCGGGAGCCUGGAGGACCUGGCCGGUCGAUCCGCCCGGGCUGGAAAACUUUCUUUAUAAUUACUUCUCCAGGUCGGAGCGCGCGGCUUGCUAGGCGCGCGGGGCCGGCGCUGUUACCCGGCGUGGAGUCGCCGAUUUUUUUUCCUGCGGGACCGCGGGGCCCCCCAGACUAGCGGAGCUGGACGCCGGGGCGAGCACGGGGAGGGGCGCACCGAGGGAGGAGACAAACUUAACUCUGGGGCCGGGAUUCCGAGGCGGGGGCCGCAGCCCUCGAGGCCCGAAGCCACCGCUUCCUCCCCCGCCUCCCCAUUCAGGUGGGCGCCAACGGCGGGAGCGAGGGUGUCCAGGCCGCCGGGCUGCCAGGUCCGAGCACGCACAGGGAGAACUCUGCCCAGUGGUUCGCCGGGCGCUGUAGUCCCCGGGAUCCUAGGGACCGAGGCGGCCAGGCCCUGGGGCCCCUUGAGUGCGGCAGCUAAUGCUCUCACCGCGGCGGGGGAAGGAGCUUGCCACCGAGACCCCCAGCCACGUGCGUCCCUCGCAUUCUUUACCGGGGCCGGGGUGGCGGCUACGGACCGUCAGCUGGGCCCAGAUGGAGUCUUGGGAGCCCUCAAGUGUCUCCUGUCCUUGCCCGCGCCGCCCCUCGCCACUGGCGCUGAGGCCUGACGCCGCCUGCGUCCCGGCUAGAGGCGCGCUUGCCUACAGGUGAGGGAAGACCCCCUUCACCGACAGUGGCCUUAGGCCUGGCAAGGCGCCACGACCCGCCCAGGAGCCCCGGAGGGGGCACAGCUAAAAACACCGCUGGAGAGCCCCGAGCUUCCACGACGAUCGCAGUAAAGAAGCAGUUUCAUCUGGGCAACGCACACUGCGCUUUAAUCAAGUUCCUAUUCAACAUAGUCCCAGUGAUUAAUAGCCCAACUGCUUCGUUUUCGGUCCAGAGCUCAUAAACAAGAUAUUUUUAGCUUGACGCUUUUGGACGGGAGGGAGUAAAAACCAGAUACGUUAAAUAAAUAUCCCGAUGUGAGCCGGAGAGCUGCUUGCUGAGCCAAAUGCAGGACCCAUUCAUAUAGCAUUCACCUGUGGAGGGAGACCUGGACGGAAAUCAAAAAGCACCAAGAGCGAUUUGCGUUUUUUUCUGCGGUGCUAAAACUAAUGGCUUUUCCUACCUAGGAACAAAGAAACGCCACUGUACAUGCACGGUUCCCGGCCUGUGGAGUUGUGGGAGGAAGGCGAUGUCUGGCCUUUUUUGCACAGCUGCUGUUGCCUGCCCAGAGAUCGGGAACUCUGCCCCGUAGGACUGGAAGAAACCUCAGUAAUGGGAAUAAGACUUUGUCCAAUAGGGGGCUGAUGAAUGUGUGGGGGCGACAAUGGCAAGGAGUGGGACUCCCGGCCCGGGGUUCGCCAACCCCAGGGGCCACAGGUCCUCCUACAAUUGAACCAGAAUUCACCCACCCGGGCCUGCCCUGUGCAGGGUGCCGAGAGCCCAGGGAUGCAUGAGAGGGUGGCUCCUGCCUCUGGGAACUGGGACAGUGGGAGAGACGGAUAAGUUGUCACACAGAGGCUGCUGGGAGGAAGGAGGAGACAGAAGGAGUAGGGGAUGGGACUUCAUUCAUUCAUCAAAUGCACACGAGGCACAAAUGGGAAUCAAGGGUGGAUGUGCUGUGAUGAAGAGAAGUCCUGCCCUGAACAAGGUGGCGCUGUGGAGGAGGCAGAGAUCAGAUUUGUCUGCGGAGGUGUUAUGGACUGAACUGUGUCCCUGCCCCAAAUUCCUAUGUUGAAGGCCUAACCCCCAUGUGACUGUAUUUGGAGAUAAGGCUUUUAGGAAGUCAUUAAAGUGAGAUGAUGUCAUAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications