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Homo sapiens (human) prostate cancer associated transcript 19 (PCAT19) URS0000A776B1_9606

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PCAT19: PCAT19 is a long non-coding RNA (lncRNA) that is significantly more highly expressed and correlates with the endothelial proliferative rate [PMC9681662]. It has been hypothesized that PCAT19's role in endothelial quiescence and safeguarding the genome is mediated through its interaction with the RPA2 protein [PMC9681662]. RPA2 is a central target of regulatory pathways and undergoes extensive phosphorylation on several sites [PMC9681662]. The potential interaction between RPA2 and PCAT19 has been investigated in more detail [PMC9681662]. The binding of miR-429 to PCAT19 has been shown to be sequence-specific [PMC8692695]. The rs11672691 variant of PCAT19 has been found to regulate the expression of PCAT19 and CEACAM21 genes, affecting the aggressive properties of prostate cancers [PMC7261909]. Other lncRNAs, including PCAT1, PCA3, and PCGEM1, have also been reported to play important roles in prostate cancer [PMC8692330]. Functional experiments have confirmed that PCAT19 can affect proliferation, migration, and invasion of lung adenocarcinoma (LUAD) cells [PMC8790230]. In gastric cancer tissue, PCAT19 expression was significantly upregulated compared to adjacent normal tissue [PMC8692695]. The expression level of PCAT19 can be regulated by SP1 protein through knockdown or overexpression experiments [PMC8692695][PMC8790230]. Functional gain experiments using overexpression plasmid or siRNA have further studied the role and effect of PCAT19 in A549 and SPC-A1 cells [PMC8790230].

Genome locations

Gene Ontology annotations

Sequence

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AAAGUGUUAUUUGACUGGAGUGAGGUCUCAUGUCUGCUUAUGCGGUGGCUCGCUGCUCAGAACAGGAUGGCAGAGAUGAGCACCACCAUCAAAAACUCAAGGACCAGUGCUGUGGGUCCAGUCAUCUGUUUCAUGGAAUUCACCAGUCUGGUAUCUUCAAAAUCCAGAAGGAUGAUGGCAGAUGGCAGGAAGGUAAUGCAAACGUCAUCAGGUGUGACCCCACUGUAGCAGCUGUGAUGGAUGUUUUCUCUCACCAUAGCAAUAAAUAACACAACCUCGGUCACACUGUAUGCAUUGUUGGUCUGCAAAAUCCAUGUUUUGCAAAACUCUUCAGGAAGGUGGAUCUGUAAUAUUGGCAUUGACAUGAGAACAACAGCAGUAUUUAUUCACAAUCUCAAGCUCUCUGUCUUCCCGUCUCUCUCAUUAGCCAUCCAAGUAGUCCUGAGGAACCAAGCCCAUCAGAACAUUCUGCAACAUAAUACACAGCUCCAUUCUCCAUUCAAAUUUUGUUGUUGUUGUUGUUGUUGAUGAGACAACAUCUUACUCCAUCAGCCAGGCUGACGUACAGUGGGGCUAUCUGGGCUGACUGUAGUCUUGAGCUUCCAGGCUCAAGGCAUCCUCUCACCUCAGCCUCCUAAGUGGCUUGAACUACAGACACACAGCGACAUGCUGGGCUAGUUUUUGUAUAUUUUGUAGAGACGUGCUCUCACCAUGUUAUUCAGGCUGGACUCAAACUCCUGAGCGUAAGUGAUCCAAGCACCUUGGCCUCAAAGUGCUGAGAUUACAAGCCUGAGCCACUGCACCCAGCCCAAUCUCCAUUCUACUGAUAACAAUGUCAUUACCAGGUCUGAUGGACAGGAAAUGGUAAGGUUUCUGAAAACCUAAGGAUCACACAGCGAGUUCCAAAGGCUGAAAGUGCAUACCUGUCGACACUGAUACCAAUGACAUCCAAUGGAGGAAGAGGGUAAUCUGGAAGAGUUUCCUGACCUACUCUGCUGCUGUGAUUAAACAACCACCAGGAAAUUUUGAUGACACUGUUCUCCUGAGCUCCUCCCUUUCCUCGGGGAAGAAAAGCAUUGAAACUACAAAAAUAAAGUGUUAUUUGGCUGGAGUGAGGUCUCAUGUCUGCUUAUGCGGUGGCUCGCUGCUCAGAACAGGGAACCAUUGGAGAUACUCAUUACUCUUUGAAGGCUUACAGUGGAAUGAAUUCAAAUACGACUUAUUUGAGGAAUUGAAGUUGACUUUAUGGAGCUGAUAAGAAUCUUCUUGGAGAAAAAAAGACUGGGUAUAUUUUCAAUAUGCUUUCCUUUUAAGGUCCCUCACCUGUGGAAAGUAAAGAAUGUCACUUUCUGACAGGCUCAGGAACCUCAAGUUAUGUAGGGAUCUCAAGAAGAUGGGGGAAUUCACCCAGUUCAUACAGGUGAAAUUGCUGUUGCAAAGAUUAUGAAUAUGAGAGAAGUCCAGCAUGGCUGACUUCAUCUCGUGUCUGGCCUCAGGCUGGCUGCCCUUGCUCACUCUUGGGCAUAGGCCAAGCUAGCCAUGGGAGGAAUUUAGUUUAUAGUUUAACUUUGAAGCACGGAUGAUAAUAGUCUCUCCCUAAAAUGAACCCCUUCCUUGCUCAGGGACUGAAACUACCUUUGUAUGACAAAUGAAAGCCCACAAGAUUAAGAUUAUGAGAGGGGCCUGAAUUCUGCUAAAAUGCAGGUGUAGCUGACUGAUAACAAGUCAUUGUCCCACAGCUUGCCUUUCUAUAAUCUCUUGCUUCUCAGGAGUCACAUGGCCAGAGGUCCUGAGAUUUCCAGUCCUGUGACCCCCACCCAGAGAUGGACUUAGUGCAUGAGGACCAUUUUCCACACCCCUAUGAUUUCAUCCUCAAACAAUCAGCAGCAACCAUUCCCUAGCCCCCUGCCUUCCAAAUUAUCCAUAAAAAUCCUAGCCUCUGAGUUAUUAGGGAGAUUGAUUAAUAAUCCCAGUCCUACCCCUUGGGUUGCUCUGAUUUAAUUAAACCUUCUCUACUGCAAUACCACGGACUCAGUAAAUUGGUUUUGUCUGUGCAAUGGGCAAGAAGAACAUGUUGCAUGGUUAUACAGGUACUACAAGCACAGUCUGAUGGCAAAUUAUUGGUUUUGCUUCCUGCCCUUGAUGUUUCUAAACAUCUAGUCCAAAAUUACUUGUGAAAGGUCCAGCAAAGCCAAUUUUAAAAGAGGCUAUAUGGCCAAUCACUAUUCUUUCUACACAUUAUUGCAAAUAAUCAGGCCACGGCUGGGCACGGUGGCUCAUGCCUGCAAUCCCAGCACUUUGGGAGGCUGAGGCAGGAUCACCUGAAAUCAGGAGUUCAAGACCAGCCUAGGCAACAUGAUAAAACCCUGUCUCUACUAAAAAUACAAAAUUAGCCAGGCAUGGUGGCAUGCACCUGUAAUCCCAGCUACUUGGGAGACUGAGGGAGGAGAAUCACUUGAACCUGGGAGGCAGAGAUUGCAGUGAGCUGAGAUCACACCACUGCACUCCAGCCUGGGCAAUAGAGUGAGACUUUGUCUCAAAUAAUAAUAAUAAUAAUCAGACCAAGUAUAAUGAAAUUAAAAUUUAUUUUGCAAAUAAAUUGGUCCUACUACAAUUUAUCCUUCAUAGAAAUGUGGAAACUGAAGAUAAAAAAAAUUAGGUUUCAGAAGAAAACUAUACUACACCUGUUAUUAGAUUCUAGCCCUAAACAUUGUUUUUGAGGUUUUUAUUAUUUACCUGCAAUUUGGUCUAAAUUCUGAAUUAUUUCCUGACUACAAGUAUCCAAGGAAUAAAUGGGUUUUCUUUUUCUUUAUGAUAGUUUUAGUUGGCUUCUAAUGCAACAACAAUUUUUAUUGUAAUCCUGUGUGCAUUCUAUUCCUACUAUUCAAAUUAUUAAUGUUAUAGAUCUUUCAUUGUAGUACUUCUGAAUUAACCAAAAUCACAGUAUUCUGAAGAUGAUUCUACAAAGCCUGCUGUUUCUACAAAGGCUGCUGAUGAUUUCUACAAAGCCUGCUGUAGUGUUGCUGUGGCCUCUGCUUAAAAAAGUAGAAAACACAUUGAUGCAGCAUGUUCACCCCAACCUCCCUGCCUAAAGGCUCAGGGACCAUCUUGGAAGAGGAAGGCGCGUGAGAUUGUAAGAGCCGAAUUAGGGGGAUGGAGUGUGGAGAAUAAGGACACUUCAUCUUGGAUGCUCACCUGCCAAAUUGACUUCUGAUGAAAGCCAGCUCCAGAAAUGUGCCUACAGUUACUACUUUCACCUAAACCCUGCCCUUAGUCAAAUCCUUCUCUUCUUCUAAGCAAUCAACUUCAAUUCCUUGUAUAACCCACAGUAUAAAAGGGCUUUUAUACCAUUCUAUCCUAUUGCAUGUAAGCCUUGGGUCUGGGAGGUAACAGUGUGGGAUUCCACCAUCUCAUCUCCCUGCCACCCAAACAUGCCUGCUCUUCUUUAAGCAAUAUUAAAUGUUUGUACUUCAGAAAAAAAAAAAAAAA

Taxonomic tree

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Publications