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Homo sapiens (human) LYPLAL1 antisense RNA 1 (LYPLAL1-AS1) URS0000A77289_9606

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LYPLAL1-AS1: LYPLAL1-AS1, a long non-coding RNA (lncRNA), plays a role in regulating the adipogenic differentiation of human adipose-derived mesenchymal stem cells (hAMSCs) [PMC8124068]. The mechanism of action was investigated using a ChIRP-MS assay, which identified RNA-binding proteins that interact with LYPLAL1-AS1 [PMC8124068]. This assay is a reliable method for capturing in vivo lncRNA-protein interactions without the need for genetic tagging [PMC8124068]. To determine the clinical relevance of LYPLAL1-AS1, its expression was analyzed in the peripheral blood of young and middle-aged healthy donors [PMC9022335]. The study included young adults (age: 24-28 years) and middle-aged adults (age: 49-57 years) [PMC9022335]. The results showed that LYPLAL1-AS1 colocalized with DSP in the cytoplasm and potentially promoted DSP protein degradation through the proteasome pathway, although further investigation is required to understand the specific mechanism [PMC8124068].

Genome locations

Gene Ontology annotations

Sequence

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GGGCACAUGGGAGCACCCUCAGCUCCCUCUCCAUGGGAUACCCUGUGGGGCACUUCAGAGUCCCCACCAGCAAGAAGGCUCUCUCUCACCAGAUGUGCCCCCCGCCAACCUUGGAUGUCUCAGUCUCCAGAACUCAGAUGAGCCAGCUCCCUUGUGAAGCUGUAAGAACAUGGUACUUACAGGAGUAAGGCUCAUGAAGUGGAGAGAUGAGAAGACUUUCGGGACAGAUUGUGUGGAGGCUGUCAUUCUCCUCGUGACAUUGCUGUGGGAGAAGAAGGAGGCAUUCCAUGUUGGCUUCAGUGAAGAACUUCAGUAUUUUCCAGAGAGAAGUACUGAGAAGCUUAAAGUAUUUGAAUGGGAGGAGGAGAAGCAAACUACAGCUACUUCAGAGGAUAACACUAAACACCUAGUCCACUCUGUAUACACUAGAGGUGCUGUUAAUUUUCUUGUGGAGAAGGAACUGUCUUUAGAAAAAUAUCUCAAAAAGCCACUGAAGUAGAAAGUUUCAGCAUGCUGAAGAUGGAACUUGAGAAGAUAGAAAGUUCUGGGUCCUUAGUGGCAUGACUGAGUCGCUGGACCACUGUUGGAACCACCCUAUGUCUUAGUUUUUAAAUCUCUUUACUGUCUAAGACAUUUUUAGUGGAAGUAUUUAUCUCUGGCAUCCAAUAAGACCUUUAAGGAUUUGCAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications