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Homo sapiens (human) CLRN1 antisense RNA 1 (CLRN1-AS1) URS0000A76B6E_9606

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CLRN1-AS1: CLRN1-AS1 is a long non-coding RNA (lncRNA) that has been found to play a role in pituitary prolactinoma. A study revealed that FOXP1-induced CLRN1-AS1 is involved in regulating cell growth and autophagy in pituitary prolactinoma [PMC6591247]. This regulation is achieved through the modulation of the miR-217/DKK1 axis and the inactivation of the Wnt/β-catenin signaling pathway [PMC6591247]. CLRN1-AS1 acts as a sponge for miR-217, leading to an increase in the expression of dickkopf WNT signaling pathway inhibitor 1 (DKK1) [PMC8656547]. This interaction between CLRN1-AS1 and miR-217 has been shown to have an impact on the regulation of cell growth and autophagy, as well as on the Wnt/β-catenin signaling pathway [PMC6591247] [PMC8656547]. These findings suggest that CLRN1-AS1 may have potential as a therapeutic target for pituitary prolactinoma, as it plays a role in modulating key pathways involved in tumor growth and progression. Further research is needed to fully understand the mechanisms by which CLRN1-AS1 exerts its effects and to explore its potential clinical applications.

Genome locations

Gene Ontology annotations

Sequence

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AAAAAAUGAUUUUCUUCUGUUGGCUUGGCAUGAUGAGAAACGGCUUCUGUGAGGGCGAGGUUCAAAAACAAGACCUUUGUGAGCAAUGGGAAGGGACUGCCUCUUUGACUGCAUUUAUUACGGAAGCUGAACGGACAGCUCCCAGCUGAAAAGGCAACUUCACCAUCGACGGUUCUCGCCAGGUUAAAUGUCAGUAGAUGAAGGCCUCAUCAUCACUCAUACUUGGCUUUUCUCCUUUUCUGCUGCUUCUUCUCCCUAAUUGGAAAUCUUUGGACUAAGAAUCUGUAAAACAAGUCUUUCAAACUGCCUUCAAGUAUCUCCUCUGUGUCACUUGGUAACAAAGGUCGAAGAUAACAGAUGGAGUCCUCAGUGUAACUUGAUAAAUGUUUCCCUUCCUCAGCCUUUUGUCUGAUUGGACAUCUGGAAGGAGGCAGUUGUUGGCUUUGUUACAGUGGUUCAAGAAUGUCAGAAUUGCAGUCACUACAAUUCUCCUGGCUUUUCUCUCAUGGUCCCCAAAUGACUGCUGGAGUUUCAGCCAUCAUAUCAGUGAUCAAGGCAGCUGGAUCCAGGCAGUAAUCCAGACACUUGGAAGUCCCACCCAAGGACUUCUGCUCUUAUCUCAUUGGUCAUCUUUGUCUGAAAGGAAAGCUGUGAAAUACAGUAUUAUUAAUAAGCACGUUGCUGGCUCCAAUAAUAUAGAGUCUUGUUAACAACAAAGAAGAGGAGAAUGGAGAUUGAGCAACCAGGAAGCAGUCUCAGCCACACCAUCAUAUGGAGAAGUGCCUGUUUCCCAUUCUGCCCGAUUUUAAGUUUCCUGAGGCACCCCCAGCCAUGCAGAACUCUCUGGUGCCUGGCCCACAGGAAGUUUUCACUAAAUAUUGAAAUAAACUGAACUUAGAUUAAACUUUGGUGUCUAACUUAGGAAAAACAACAAGAGUUCUACAAAACUAUUUCUUCACAGGCUGUUGUAGCAGGGAGACCCUCAAGGGCGUCUACAAUAUCACCACAACUCUCAUAGAGCUGCCUGUGAAGGAUGACAAGAAGGAAGUAGGCUGAGACCCAAGUUCUGGGUCAGGGGACUAAUGCUGUUGUCACCAAGAAGGGAAAGUCUGAAGCCAGGCCUGCUUAGCAGAGGUCUCCGUAUAGUAGGGAUCUCACUCUUUCAAGAUGUAGGAUCUCAACUGGUUAGCCAGCCCUCUGAGUGAAGCUGGUCAGUUGGGGCUGUGACAACAUAGCACACUCAAAGGGGCAGACCCUUCUCAGCUCCAACAGAUUGGUGUCAUUGGAAAAGGUGGACCCAGUGUAGGCAGACUUUCCUAGAGAGUCCAGAAGUGACUGUGCAAGCCCAAAGCAAUCCAAACAAAUAUUUGUGGACCACCAAGAACCUCUGGUAUGAAGUAAAUAAUAAAGGCAUUGAACAAUAAUAACCUGUCUGUAUAUCCACCAAUGGGACCGAUGGGCCACAGUGUGACAUCUAUCCUAUUCAUGUCAUAAGGGAGAUGAAUUCUACUGUGGGACAGUCUGUGUGACUGCUCGUAGGAGAUUAUCCAAUUCCUUUUGCUCUAAUUUCAUGGUCACCAAAUUUCUGCUUGCUAACUUUGUUUUACAACAAACUUUAGAAAGGAGGUGAUCUGAAUAAGAGGAUAUAUGUUUUUCAGUCUCUGGAAAGGGGUAUUUCUUUGUAUUGAGAAGCCAGAACUCUUGAGUGUGUUGAGCCUUGUAGAGAUUGAACCACUCUGGGUCAGCUGACAAAAUAAGAUUCUGGUGCUGAAAAGCUGAGUAUGUGACCAUGAUAUUAACAGUGACCUAAGUUUGUGUGGCCCCCUUCGUUCUCCAGAAACCAACCAGUCAGCCUUCAUUUUGUAAAUGUAGCAGACACCAUUUUGCUAGUGAAUGAGGUUAAAUCUUUAGCCUUGUCAUUGGUUCGGCUUUGUAAUUUAAAACUCUCUUAUUUUACCCUCUGAUUUUAAAUCCCCAGAUUUUCCUUUCUGUGUCCUUUGCCCCCUGAAGUUUCCAUCUGUCUAGCAACUAAGCACUGUUUGGGUAUCUACUGUCUUCCCCAAGUUGCCUUUACUUUUCUUCUUUACCUUUCUCUUGUUUUAUUUAUUUCUUUCUUUUUUUGAAAUGGAGUCUUGCUCUGUCACCCAGGCGGGAAUGCAGUGGCGCAAUCUCGGCUCAUUGCAACCUCCACCUCCCGGGUUCAAGCAGUUCUCCUGCCUCAGCCUAAUGAGUAGCUGGAAUUACAGGUGUGCACCCCCAUACCUGACUAAGUUUUGUAUUUUCAGUAGAGACGGGGUUUCACCAUGUUGGCCGGGCUGGACUUGAACUCCUAACCUCAGGUGAUCCGCCCUCCUUGGCCUCCCAAAGUGCUGGGAUUACAGGCAUGAGCCACCACACACAGCCUCUCUUGUUUUACUUCUGUCAUUACUUUUUGUUCUUUUAAUUUGGAAACCCACCUGCUUCCUCAGUGUCAUUAUUAAAAACCCACAUGUUACAGGUUCAUUAGGACUGAAACAUUCCUUCAGAGCUGAGCUGACCAACAUGUUAGCCACUAGCCACAUGUGACUAUUGCAUACAUGAAAUGCAAAAUGUGGCUGGUCUGAAAUGAUGGUAUAGGUAUGAAAUUCACACAAGAUUUAGAAUACUGAAGAUAAAAAAGAAUGUAAAGUAUCUCAUUAAUACUUUUUUUGGUAUUGAUCACCUAUUGAAAUGGUAAUAUUUGGUUAUACUGGCUUAAGCAAAUGUACAUUAAAAUUAAUUUCAUCUAUUUCUUUUUACUUCUUUAAUACCAGAAAAUGUAAAAGUACCUAUCUGGCAAGCAAUAUAAAACUAUUGGUCAGUGCUACUUGAGAGUCUUAAUGUCUGUAUUUUUUAUAUCUCUGUAAGCAUAAAUGCUGUAUUAAAAACCCAAUUUGAAUAAACACCCCCAAAUUACUCUUCC

Taxonomic tree

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Publications