v24

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Homo sapiens (human) CHL1 antisense RNA 2 (CHL1-AS2) URS0000A76B17_9606

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CHL1-AS2: CHL1-AS2 is a noncoding RNA that is regulated by eSNP rs11685391 and is co-expressed with the gene CLEC12B, which is involved in pathogen recognition in mucosal macrophages [PMC7892863]. Long noncoding RNAs (lncRNAs) are RNA transcripts that do not have protein-coding potential and play various roles in cellular processes [PMC8368758][PMC6676736][PMC8130971]. CHL1-AS2 belongs to the category of antisense lncRNAs (AS-lncRNAs) that are transcribed from the antisense strand of protein-coding genes [PMC8368758][PMC6676736][PMC8130971]. AS-lncRNAs, including CHL1-AS2, have been shown to regulate gene expression through various mechanisms [PMC8368758][PMC6676736][PMC8130971]. AS-lncRNAs have been implicated in a wide range of biological processes and diseases, including female reproduction and ovarian dysfunction [PMC8368758][PMC6676736][PMC8130971][PMC5928764][PMC6994393][PMC9587675]. In the context of endometriosis, CHL1-AS2 has been found to be upregulated in ectopic lesions and adjacent tissues compared to eutopic endometrium [PMC6994393]. Additionally, dysregulation of CHL1-AS2 has been associated with poor prognosis in patients with kidney renal papillary cell carcinoma (KIRP) and pancreatic ductal adenocarcinoma (PDAC) [PMC9082950][PMC9213676]. Furthermore, CHL1-AS2 has been identified as a potential therapeutic target for PDAC [PMC9213676].

Genome locations

Gene Ontology annotations

Sequence

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CGGCGGAUUCGGGCGCCCGGUGUGCUCCGUCGACUGACCCCGAGCUGUCCGAAUCCGGCCUCGGCCACCGGGGGCGGGGCGUGAAAAGGGGGCGUCUCCUCCCGGGUGCAGGCUGAGGGGCCCGGACCACCCCCACUGCGGACGAGGGACCCUGACCGCGCCCCGCUUCCUUUCCAUAACGAGUGGACCCCUCCCGGAGCACCUUCAGCCCUUCCUCCACGGGAGACCCCCCCAGCGCCGGCACGAGAGAUGCCAGCGGACCCCCACCCCUGACACACCUGCGCCGCCUCCGAAACGCGAUCUGUCCGGCGCCUCCCCUCGGGCGCCUUCUCCCCCGAGCCGGCCGGGAGCCGGGACGGGGGCGCGCAGGGUCCGGGAGAGUUACAGGCUUCAGACUUUAUCUCGUUGUGGAAAGCAAGAGACCAAGCCAAAAACUUUGGUCGUGCUUUUCAACAUCUCCGGUCAAAAGAGGUCGCCAAUCUGCUUUUCUCCCAUUGCUGCGUCUUAGAGGGGUGUGGUGCCAUGAUACCACUUUUGAAAAUCCUGUUGAAUGCAAGUCCUCUUUGUUGCUCAUUGAACAAUGAGGAUAUUUAGCUCCCCUCAGAGCUACCCUCAGAGUUGGAUGAGCUAUCCUCAGAGUUGGAUGCCACCACCGGGAGCAGCAAAAGCGAAGGCAACUCAUGAUUCUGCCUCAGAAGCAAUCGAAUAAAAUAUUUUGAAAAUGAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications