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Homo sapiens (human) HSALNT0289210 URS0000A76AD1_9606

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PCAT7: PCAT7, a long non-coding RNA (lncRNA), has been identified in prostate cancer (PCa) [PMC4163346]. Functional experiments have demonstrated that upregulation of PCAT7 promotes epithelial-mesenchymal transition (EMT), invasiveness, and bone metastasis of PCa cells [PMC7138406]. The results suggest that SMAD3 may be involved in the TGF-β-induced transcriptional activation of PCAT7 [PMC7138406]. Furthermore, the study reveals the critical role of the SMAD3/SP1 complex-mediated constitutive active loop between TGF-β signaling and PCAT7 in PCa bone metastasis [PMC7138406]. Additionally, PCAT7 acts as a carcinogen in non-small cell lung cancer (NSCLC), promoting cell proliferation, inhibiting cell apoptosis, accelerating cell migration/invasion, and inducing EMT [PMC5749158]. The findings suggest an inverse correlation between miR-324-5p expression levels and both PCAT7 and TGFBR1 expression in PC-3 and C4-2B cells [PMC7138406]. Moreover, it has been shown that PCAT7 exerts its function on NSCLC mainly by targeting miR-134-5P [PMC5749158].

Genome locations

Gene Ontology annotations

Sequence

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AGAACAUGCAGUCUAGGAACCGGCAUGCGCAUAACCUCAGGAUAUAAAUAAUGCUGAAGCAGAGUUACGUUUUUUUUGUUGUUGUUUUUUUUGUUUUUGUUUUUUUAGGUUUCCGUGUGUUUCUAUUGAGCUGCUCAGUGCCCGGCUUAGAAGACCAGGAAAAGGAGUCACAGGUCGUAUGCUGGAGGCUUGAGCCGCGGCACCGUGGCGCGGCUCGCCUCGCUGCGGUUGGUGGUGGCGGUGGACAUUGCAGCGCGGCUGGAGGGGUAGGAAGAAGAAGAUAGUUUUGGGAUAGAUAGAGGGUCCUUAGACAAGGUGCAAGACAAACAGAAGAGGGCAUGUGGGGUCAAACUCGCUAGCUGCCUGCCUGAUUUUUCUGCACACAGGUGAGAUAUUCCUGCACAUCCUCUGGUGACCCCAGAAUGAGGGGGACUCGCUGGUGAAUUGCCUCGGGCUUCACGUCCAGUACAGGCUGGGUCCCCGUGGUCGCCAAGCCUCCUGCCUGCUCAAUGAUGUAGGCCACGGGAUUGCAUUCAUACAGGAGCCGGAGCUGUGGAGGAACAGAGGCAGGACAAAUUCACCAAGAGCCUAGCAACAUGAAGAGAGAUGCCAGGAAGAAGAGAGAAGCCAGGAAACAAGCCAACCGCACAAUCCCCACAUCAGAGCAGGAGAAGAUGGGGGCCUGCUGGCAGAGCUGGGGCUUGGCUGUGGUCACUCUGAACCUGCUCUUUGGUGUUUUCAUGAGUGGUGGGAAGAAUAGGGACCAUAUGGAGCCCACACAGGAAGCUCUAGCAGUAACACAGCAAGCAGGAAGACAAUUCUAAGGAAGCAGCCCAUAGUCUUCUUUCUUUUCCUGUGCAUCUUCCACUGUCAGUGAGGCUCCUCAUUUAUGGUGAACCCAACUGUGUGUAUCUCCCAAGUUCUCACCCGCAGAUUAAUGUUUUCAGGAAGAUAGGCCAUCAACAGUGAGAGGAAGAAGUUACAUUGUCGUAUGAGGGAUGCAUUUUAACCAUUAAUUUGUGGUACAGGCUGGGCGCAGUGGCUUAUGCAUGUAAUCCCAGCACUUUGGGAGGCCGAGGUGGGUGGAUCACGAGGUCAGGAGAUCGAGACCAUCCUGGCUAACAUGGUGAAACCCCGUCUUUACUAAAUAUACAAAAAAUUGGCCGGGCGUGGUGGUGGGCACCUGUAGUCCCAGCUACUCGGGGGGCUGAGGCAGGAGAAUGGUGUGAACCCGGGAGGCAGAGCUUGCAGUGAGCCGAGAUCGCGCCACUGCACUCCAGCCUGGAUGACAGAGCAAGACUCCAUCUCAAAAAAAAAAAAAAUGUGUGGUACAGUUAUUUUGUUUAUGUUAGUGAUUCAAUCAUAGAAACUAUUCAGUUUCUGGUAUCCCACUCUUACCUGGAGAAAAGAGGAAGCCGCUUUCAUCAGACACUGUGUUCACCCAGCGUAAGGAAAAAGUUGGUAAAAUCUAAAGGAAUCCUCAGACAUAUUAAUAAAAGUGUGCCCAGUCCCUCUCCACAACCCAUGUAGCCACUGUGGUCAGUACCUGCAGGGCAUCUCUCAAAUACCCCUAUGUCUAGUUCUGGUGAUAUCAGUCACUAAAAAUGGGAUCAGCUUGUGGCAGAUACCACCUUAAAUGCUCAUGUCUGUCUCAGUCACUAGGAGGAAAACCAGAGCCUGGAAACCAGAUCCAUUUUGAUGAAUGUCCAAGAUUUUGAGAGUGAAAAACUCCAAAAUGACAGCUCACAGUUGGCAGCUAGGCCAGAAGGUUCCCAAGGAACAUCAGAGGUAUUCCCGGAAUAUAAAGAGGCAAGGCCACAGAAUGACUCCACAUAGCAGAGGUGUUGCUACGAGAGGUGACACUGUCCCUGUCAGAAACAAGUCAGUGCCAAGGAGACUCAAUAACAAAAACAACUAAACAAUCCUUUCCUGCCUAA

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Publications