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Homo sapiens (human) PPM1K divergent transcript (PPM1K-DT) URS0000A76A54_9606

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PPM1K-DT: PPM1K-DT is a long non-coding RNA located 100 kb downstream of the ABCG2 gene. It has been identified as a predictor of the transition from asymptomatic hyperuricemia to gout. A study analyzing gout cases and controls from the UK Biobank identified 13 independent SNPs, including PPM1K-DT, that reached genome-wide significance as predictors of this transition [PMC9333104]. Another study found that PPM1K-DT SNPs can be used as markers to identify individuals at risk for asymptomatic hyperuricemia and gout [PMC9259951]. Additionally, aberrant expression of PPM1K-DT has been associated with promoter methylation changes in CpG sites [PMC9205881]. Specifically, hyper-methylation of CpG sites cg19500311, cg23194354, cg05850997, and cg11052780 was found to significantly lower the expression of PPM1K-DT [PMC9205881]. The down-regulation of PPM1K-DT was significantly associated with the hyper-methylation of these CpG sites within its promoter region [PMC9205881]. Furthermore, a genetic variant (rs10011796 C-allele) associated with reduced serum urate and reduced risk of gout was found to be associated with increased expression of PPM1K-DT [PMC7069001]. These findings highlight the importance of PPM1K-DT in understanding the genetic and epigenetic mechanisms underlying gout and its transition from asymptomatic hyperuricemia.

Genome locations

Gene Ontology annotations

Sequence

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GUAGUUGUGACAGCCAGGAAACCGAGAACGGAAUGCCAAUACUGCUUAGGCUUAGAGUUUGAAAGGCAUCUGAUUUCACUGCCAUGUCUUUGAACAGCAGUGCACAGUGCAGUCUUCUUCGUGGCUGAACAGCCACUCGAUGUCUUUUGAUUGGAGAGUUUAAUCAAACAGAAGGAGUCUUCCAUUGUGGCCACCACAGCUGGGAAUGAGCUAAGGUCUUGCUAUGUUGCCUAGACUGGUUUUGAACUCCUGGGCUGAAGCAAUCCUCCCACUUCGGCCUCUCAAAGUGCUGGGAUAUCAGACAUGAGCCACCUGCCAUGCUUGGCCUAUAAUCAUGAAAAGAUCAACCCCAAGAAAGAAAAGGAAACAUGGAAGGACCUGGACUGGAGUCACGCCAGUACAAGGAGGAUACUGGCAAAGAUGAGGCUAGUCAAGUGGAGCAGUGGGAGUGAAGAUGGAAUAAAGAAAUCCAUAACUGGUUGUGAUUAAGUAGUUGUAAACACCAACUGCACUCAGACCAACCCAUAUAUAUAUUUUUAAUUGUAAGCAUAGUAUAUAUAAAACUUCAAUUCCUGCUUUUUUUUACCUAACAUUAUAUCAUAUGCAUUUUCCAUACUGUUUCACAAUUCCUUGUAUUCGUAAUUGUUUAAUCCUGCAAAAUAAUGCUUCGAAUGAACAUAUGAUCAUUUCCUUAAGUAUUCCCCUACUAUUAGAAGUGAAGUUUCUUCCAGCAUUUUUCUCUUUGCUGUGAUGAAUAUUUUUAAGUAUAGAGAUUUUUCAGUUUGGUUAUGAGUUUUUGAAAAUCUACUUUACCAAAAACAAAGAAAACCCAUGUCUUUCUUUAGUACCUUUGCCAAGAUAUUACUUUUACUUGACAUUCAACAAGUAUAGGAUGAAAGUACACAAGUCUGCAAGGGACCUUGGAAGUAACUUGUUUCUGUCUAAUUUCUAUAAAAUUUCCAGGAGAUAGUCAUACAGCUUUAAUUUGAUCGCAUCCACUAGUUUUGGCAUUGGUAUUGCCAUAUUGAUUAUGGACACAUAAAACUGUAACUCCUGGAGCCAACCUCUCAGGCUUUCCUACAUGAAACCAAUGCCACCAUCCCACCCGCACUCUAGCACCUUCUAUCCACUGAUUUUAGUCAUUGACUUGCUCUCUUCCUCUUUCUGUUUGUUGUCUUCCAGUUUGUCUCUUUCAUUCCUCCCCUCCCUUCUCUAUCCUGCUCUCUGACCCAAGAGGCUGACCUGUAUGAACCACAUCAGUGAUUGGCUGGUGGGGCCCCCCAGCAAAGAGGAUGGAGUGAAGUGAGGGUAUUUACUUGCUUAAUUGCCUCCAGGCUGGGUCACUCACAGCUGGCCAUGUCCUUCCAUCAAAGAUCAGAGCUCUCCUCAAGGUAGCCCUCUCCACAAACUUUCUUGAGUUUCUCUUUCUGGGUUUUGUUAACCAUUUUCUCAACUUGUCCCUUCAUGCCUAGAGGUAAUAGCAGGUGGGGAAUGCUGUGCUAUUCCAUUUGGUUUUCCUGCACCCUUCCCAUGUUUGUAUGUAGUCCCUUUCAUCAAAGUACUGGGACUGUCCUAAUUCGAAUGUGCCAUCUUUUUUGUUUCCUGCUAAGAACUGUUCAACUCACUCUGGAUACACUCAAUAAAUAUAACUCAGACUGUCACAAUAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications