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Homo sapiens (human) long intergenic non-protein coding RNA 1149 (LINC01149) URS0000A76761_9606

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LINC01149: LINC01149 is a long non-coding RNA (lncRNA) that has been implicated in various immune-related diseases [PMC8555954]. It has been shown to have an impact on the expression levels of multiple candidate genes, including HCG27, CCHCR1, and HLA-C [PMC7733486]. LINC01149 is significantly associated with childhood asthma and is considered a risk factor for chronic obstructive pulmonary disease (COPD) [PMC9362860]. It has also been found to contribute to increased soluble MICA (sMICA) levels, which increases the risk of hepatocellular carcinoma (HCC) [PMC9716033]. Additionally, LINC01149 has been identified as a risk factor for chronic thromboembolic pulmonary hypertension (CTEPH) and plays a regulatory role in its progression [PMC9362860]. Genetic associations have been found between LINC01149 and decline in lung function in childhood-onset asthmatics who smoke, as well as with self-reported childhood asthma in COPD patients [PMC6658410] [PMC6206739]. These findings highlight the role of LINC01149 in immune-related diseases and its potential as a therapeutic target.

Genome locations

Gene Ontology annotations

Sequence

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GGAUUCCAGGGCUGCUCAGGAGACGCCUCCAUCCUGGCGUGGAUGACCUCAGGAUCAGCCCCGUCUGCCCCACUCAGCCCGCAGCCUGGUCCCCGAAAGCGCUCAGUCAGAAUCCGAGAGCACUGUGGCGGCGCCCCCGUGUGGCCACAGGACUGAAGACAGAGGACCCCGCUCCCCUUUCUCCCCAGCCAGGACGUCCCAGGCUCUCCCCCUGUUCCCCGCACCUGGACGGGACUCUGCACAGAAGAGAGUCUCCCGGUCUCGUGUCAGGCUCUGAGUUCAUCCAGCUUCCCAAAAUCCAUGUUGAUAUGAACGUUUUCUCCCACAACUGAUUGACUGGACUUUUGUCUCAGGGCAGAGGGAGGCCUCCAGACCAAAACAGCAGGAUCAGGUCUGGAGCUGACUCAACCCCAAACCCUUGCUAAUGCACGACCCAGUCCCCCAGCCUCCAGGAUGGGACCUUGGCCUCCUGUCCCCUCCCUUGUUCCUGCCACUGCUCCUGCAGGUGGAGGCUGCUCAUCCCAGGAAUCAGUCUGUGAGCUCCAACCUUGGGGCCUCGGUCCAGGAAGGAGGGAGGCUCCAGAGAGCAGAAGGGAGAUGAAAUGGAUCAUAAGAGAAGAAGGAAUCAUACCAAACACUGGAACUGACCUUUGUGAUGCUCAGGAAUGUCCUGAUGUCAGCGGAGAUGAAGGAAAACCAGAGAUUCAAAAGUCAAAGGAAAGGGCCAUUUACCAUAAUUCAUAUCAUACAUAUUUCCUGGAAAAAAAAAGAAAAAUUCCUUGGGGAAAAAGCAUCAAAAUCAUCAGGAAGUCUUCCACACAGAAAUGACUUCAUUAAUUUGAUCUCUGUCAUUCUUUCUUUUCAUUCAUGUAUUAUUAUCCAUAGAGAUUUCUAUCCUGUGGGUUUUUUAUUUAAUUUUUGUUUGUUUGGUUUUUUCAGACACAGUGAGACCCUGUCUCAAACAAACAAACGUCACAGGCUGCAGUGCAGUGGCACAAUCAUUGCUCACUGCAGCCUCGACCUCCCUGUCUGAAGCAAUCCUCCAGCCUCAGCCUCAUGAGUAGCUGAAACUACAGGAACAUGCCACCAUGCCCAACUAAUUUUUUAAAAAAUUUUUUUGUAGAGAUGAGGUAUCACUAUGUUGCCGAGGCUGGUCUCAAACUCCUGGGUUCAAACAAUUCACCCACCUUGGCUCCCCAGAAUGCUGGGAUUACAGGCCUGAGCCACGUACCCAGCCUCUAUCCCAUGUUUUGAUUCAUCAUCAUCUCCUAAGCCCUUUCCCAGCAUCGAUAGUCUACUAAACAUGCCAUGAUUAAAUUAUAUCUCUAUACCUUGAUAUAAACAAAAAAUUAUAUGAGCAGUAAAGACAAAUAUGAAAAAGUAAAAUUACUGCCAAAGUUAUUAGGAGGAUAACCUAAAUUAUUUGGGUAGGAAAAUCUUUCUUUUUUAUUUUAUUUUUUUUUCCAGCCAGGGUCUCAUUCUGUCACUCAGGCUAAAUUACAGUGGCCCGAUCAUGGCUCACUGCAGCCUUGACCUCCCAAGAUUCAGGUGAUCCUCUUGCCUCAGCCCCCUGAGUAGCUGAGACAACAGGCAUGUGAGACAAUGCCUGGCUCCUUUUUAUAUUUUUAGUAGAGAUGGGGUUUUGCCAUGUUACCCAGGCUGGUCUCAAACUUCUAGGCUCAAACGAUCCACCCACCUCAGCCUCCCAAAGUGCUGGUAUUACAGGCAUGAGGCACUGUGCCAGCCUUUUUUUUUUUUCACAUCUGCUGGAAUGGAAAAUAUUUCUUAAAUGAGACACAAAUGUAUCAAAUUGAAAAUGUUUAAACUUCAAAGGACUUACAUACAUAUACAGUCAUUCUUCGCUCAAUGGUGAGAUAGCUUCUGAGAAAUGAGUCCUUAGGUGAUUUUGUCAUGUGUGGACAUCAUAGAGUGUCCUUACAUGAACCUAGAUGGUAUAACCUACUUCACACUUAGGCUACGUGAUAAGCCCAUUGCUUCUAGGCUACAAAUUAUAUAGCAUGUUACCGUAUGGAACAUUGCAGCCAAUUCUAACACAAUGGUAAGUAUUUGUGGAUCUAAGCAUGUGUAAACAGAGAAAAGGUACAGUAAAAAUGUGAUUAACAAAAAGAUCUUUAAAAUGGAAAAAAAAAAAAAAA

Taxonomic tree

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Publications