v24

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Homo sapiens (human) BARX1 divergent transcript (BARX1-DT) URS0000A766B2_9606

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BARX1-DT: BARX1-DT is one of the three hub genes expressed in patients with laryngeal squamous cell carcinoma (LSCC) [PMC10000590]. Patients were classified into low or high expression groups based on the median expression level of BARX1-DT [PMC9128282]. BARX1-DT, along with KLHL7-DT and LINC02154, were identified as hub genes using Lasso, RF, and top 25 prognostic-related immune-related lncRNAs (IRLs) [PMC9128282]. These three IRLs were used to build an IRL classifier for prognosis prediction in LSCC patients [PMC9128282]. Survival differences between low and high expression groups for BARX1-DT, KLHL7-DT, and LINC02154 were compared using Kaplan-Meier survival analysis [PMC9128282]. The IRL classifier risk score was calculated based on the expression levels of BARX1-DT, KLHL7-DT, and LINC02154 [PMC9128282]. The downregulation of BARX1-DT, KLHL7-DT, and LINC02154 may contribute to the development of an immunosuppressive tumor microenvironment (TME) in LSCC by decreasing the expression of key immunomodulators such as CCR3, CXCL10, and CXCL9 and reducing the recruitment of effector CD8 T cells. This downregulation may lead to resistance to checkpoint immunotherapy in patients with LSCC [PMC9128282]. References: - PMC10000590 - PMC9128282

Genome locations

Gene Ontology annotations

Sequence

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AGAAAACCGGCGGCUUGAUCGGCUUUUAGGUAGCCCCGGAAAGGUCGGGAGGAGGAGGGGCAAAGGCCGCGCUCCUCAGCUGGGAAGGAGGUGGUCUCAAGCAGCCUCCAGUCCCGGGCUCAACACCGCCAACCCGGCAAGGGUGAGGCAGCGUUCAGGGAUGCAAGGGGCAGAGCGGUAGCGGCACCUGUGCACCCCUCCCACCUCUGCCUCAGUUUACCAUGUACGGCCUCAUUUCUCUCCGGGCUGCCCUGAGAGAAAAAUGUUCUCCAGCCGAGAUUUGCUUGAAUUGGAAAUUCAAGUGAUCCAUGGACACAUCCUCCUUGACAGCCCCCAGAAGACUGUAGGCUGGUUACAUCCCCCUAGUUAGAAAAGGAAAAGGAUUCGAGGAGAAGGGAAGGAUGCAGCUUUGCCUUUUCCCAGCUUUGGGGCAUCAAGAAACUGUUACUGGGCGGAGUUGGGGCCAGGGGGCCAGUGGGUGCUCUGAGAGUGUAAAGACCAAACUCUGGUGGGACCUGGCUCCAUUGCGGAGCCUCAAAAGCUCCAACAUGGUGGAGGAAGUUGGCAGUACCUUCUCUAGAUCUUUCUUUCCAUCCUUAGAAGAGUAUAAGCCCAAGCCGUGGAGUGAACAACCCCAAAGCUACCCUACGCUGAACUCCUCUCUUUGGUCCUGCCACUACUGGUGAAACCACUGACCCUUUCUGGGCCUGUUUCCUUACCUGUCCUGAGGAGAUGCUGACCUUUGGCUCCAGAGAGACUGUGAGAACUCAGUGAGGGGGUCCUGCACUCCGAGGGUCCUGCACCCUGGGAGCCCUUAGGUCUGUUUGGAGAGAAAACAGUUCCUCCAGGCAAGAGGGGAGAAGUGUCCCCAGGAGGUUGGGGGAGGAGCAUCUGCCCUCCUCCUUCUCAGGAAUCACAGGGCCUACCUCCUAGCCCCAUCCACCAUUGCCAGUCAGCGCCUGAUGCACUGGGGGUGUCCUGGGCCACCCGGACUUCCUCUGUGAGCUCCAUGUGGGGCCUCAGUCUUUACCUCAGAUGGGAAACUGAGGCCCAGCAAGAGGCAGCCCUGGUGCAGGGACUCCAGUGAGUAGGGCUGGUUUACUAUUGCUUCUUGUACAGAGCCAUAUCAAGCUCCUUUUUCCGGCUUCCUCCCUCACCUCCCCCAUCUUAGCAGGGCCCCUGCCCCUUCCUCACCCCCUGGCUUCUGCAUCUCCCUAAGGGCAUAGCCUAGUGGUGGUUUCUCCCCUGAGUAGGCCCAGCUAGCCUCUGUCCCAUCCCCUGUUAUUUGGGCCCUAACAGAAGCUACCCAAAUUUGAACCAUCUCUGCCCCAUGCUCAAGACCUGAGGGUCUCACAUCCUCAAAAUGGGUCCCCAGAUUCCAGAUCCAAGGAUUUGGGGAUCACACUGUUCAUCAGCUGUCACUAAACUUAUUUUACUAUGAGCCAAAAAAAAAAAAAAAA

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