v24

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Homo sapiens (human) ADIPOQ antisense RNA 1 (ADIPOQ-AS1) URS00009BF5F8_9606

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ADIPOQ-AS1: ADIPOQ-AS1 is a long non-coding RNA (lncRNA) that is associated with lower plasma adiponectin levels at signal 'F' and higher expression levels of ADIPOQ-AS1 [PMC7511027]. The functional consequences of ADIPOQ-AS1 are distinct from other signals, as indicated by allelic effects on transcriptional activity, distance from other signals, and consistent direction of effect [PMC7511027]. The association between the variant rs17846866 and ADIPOQ-AS1 expression level remains significant even after conditioning on the variant rs143784260 [PMC7511027]. Expression levels of ADIPOQ and ADIPOQ-AS1 are weakly positively correlated, likely due to the low relative expression level of ADIPOQ-AS1 and the wide distribution of expression level of ADIPOQ [PMC7511027]. The effect of adiponectin decreasing alleles on transcriptional activity suggests a link to ADIPOQ-AS1 rather than ADIPOQ or LINC02043 [PMC7511027]. GTEx v8 data shows different lead variants associated with the expression levels of ADIPOQ and ADIPOQ-AS1, potentially influenced by various factors such as cell type composition, sex, sampling variability, and expression measurement/analysis methods [PMC7511027]. The adiponectin association signal 'F' colocalizes with an eQTL signal for ADIPOQ-AS1, an antisense transcript that post-transcriptionally regulates parts of two distal exons in the gene for adiponectin (ADIPOQ) [PMC7511027]. Further conditional analyses suggest that signals 'A' and 'F' have different molecular effects on the expression levels of both genes [PMC7511027]. Haplotypes containing transcript expression-decreasing alleles at ADIPOQ and ADIPOQ-AS1 exhibit lower expression levels, supporting the distinct molecular effects of these two association signals [PMC7511027]. ADIPOQ-AS1 is involved in a co-expression gene regulatory network in adipose tissue, showing a positive correlation with other mRNAs [PMC6745163]. It is located within the genomic location of ADIPOQ [PMC6745163].

Genome locations

Gene Ontology annotations

Sequence

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AGUGAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGAUUACAGGCGCCAGCCACCAUGCCCGGCUAGUUUUUGUGUUUUUAGUAGAGACGGGAUUUCACCAUGUUGCCCAGGCUGGUCUCAAACUCCUGAUCUCAGGCUCAAGCUACCUUCUUGAUGAAAAAUUCUGGACGUGUUCUGAAAAUCACAGUCAUCCCUAACUUCAGUGGAAAAGAUUCAUAUUGUCCAGCUGAACAAGGAUUGAUACUUAAAACCAGGGAUUUCCUAAAAUGAAAAUGUUUCUGUGGAUAAAACUGAUUACAUGCAGAGACUGGAAUGGAGUUAAUUCUGGGUAGAUAUGGGAUUCAAGAGAUUGGUCUUCAUGAGGCAUUUAUCAAGGAUCUGCAAGGGAUUUAGAGGUGACGGAAGCACAGUCCUUCCUGGGCAGUUGCCUCUAGCCUGGUGGGAGGUGUUCCUCACACCCAGGACUCUCAUCCAUGGCAAAAUAAAAAGUGAGAUAUCGACUGGGCAUGGUGGCUCAUGCCUGUAAUCCCAGCACUUUGGGAGGUCGAGGCGGGUGGAUCACCUAGGCCAGGAGUUCGAGACCAGCCUGGCCAACAUGACGAAACCCCAUUUCUACUAAAAAUACAAAAAUUAGCCAUGUGUGGUGGAAUGCACCUGAAGUCUCAGCUACUCGGGAGGCUGAGGCACAAUAAUUGCUUGGACCCAGGAGAAGGAGGCUGCAGUGAGCCGAGGUCGUGUCACUGUACUCCAGCCUGGGUGACAGAGUGAGACUCCAUCUCAAAAAAAAAAAAAGUGGAUAUCACAUCAGAGAAGCUCCUGGCCAGGUGGCCUUGAGGAACAGGGAUGAGUUCGGCACUUAGAGAUGGAGUUGGCUUUCCCCGUUGGAGGGAAAGGCAUGAGAAGGGACAUAGGUAAGAGGAAGUAGAGUAGUGCAGGGGCCAUUGAGUAGUAGUCCUUCCAAGACAGGACGUCAUCAUAGAACCACUUUCUCUGAGGAAGCUCUGCUUGGGGGAGGUUUUAAUUCAUGAGGAAGGCAAAUUCAAUGGCUCUCAGGUGAGGUGGGAAACAGACACCUACCAACACUCCAAAGAGAACAUGUACCUCUAUAAAAGGGCACAGUCUAGUGAACAAAGUCCACAGCUCUGGGUUUGAUUUCUAGCACUGUCACUUAAUACUGUGUGACCUUAGACAUUCACUUAACUCUCUCAGCCUCAGGAUACAAUCUGUAAAAACAGGAGAAUGCUUGUUCCCUGUGCCUUAUAGGAUUGAUAUGAGCAUCAGGAGAGACAGUGGGCACAAAAUAGCACUGUCAACUACUUCUUUCUAGUCAGUUAUCUGGUCAUGUUUGUGAAGCUCCCCAGGACUGGGAACAUAGCAUAUGAUUUUUUUAAAGUUACUCGAUGAAUGAAUGAAUAAAUGAAUGAGUAAAUGAAUGAAUAAUAUCUAAAGGCCUCCAACUAAAUAAUAAUCAACUUCCUAACCGUACUGAAAGCCUUUAAUUGACUUUGGGGCUGUUUGGCCUGGAGGAGGCUCUGAGUUAGUGGUGAUCAGUUGGUGUCAUGGUAGAGAAGAAAGCCUGUGAAGGUGGAGUCAUUGUCAUUAUCAGCAUAGAGUCCAUUACGCUCUCCUUCCCCAUACACCUGGAGCCAGACUUGGUCGCCCACCUCCAGAUGCAGGAGCACAGAGCCGGAGGCCUGGUCCACAUUAUUUUCCUGGUACUGAUCAUAGGUGAAGAGCAUAGCCUUGUCCUUCUUGAAGAGGCUGACCUUCACAUCCUUCAUAUAGACUGUGAUGUGGUAGGCAAAGUAGUACAGCCCAGGAAUGUUGCAGUGGAAUUUACCAGUGGAGCCAUCAUAGUGGUUUUGCUGAUUGUAGAAGAUCUUGGUAAAGCGAAUGGGCAUGUUGGGGAUAGUAACGUAAGUCUCCAAUCCCACACUGAAUGCUGAGCGGUAUACAUAGGCACCUUCUCCAGGUUCUCCUUUCCUGCCUUGGAUUCCCGGAAAGCCUCGGGGACCUUCAGCCCCGGGUACUCCGGUUUCACCGAUGUCUCCCUUAGGACCAAUAAGACCUAAGGAAUGAGAAGACCUCAGUGACUACAAAGAACAGAACUCCUGCCUAGGAUGUCUCUCCUCCUCUAUUCUGCCUACCCAUCAUUCAAGGCCUAGCUGAAGCUCUGCCUCCUCCUUGAAGCCUUCAUUCUUCAUCAGGUCCACGGGGUGCCAUCUCUGCCAUCACGGCCUGGGGCCCCAUUAUGGCCCGGAUGCCCUGGGAUGCCCGCCAUCCAACCUGUGCAGGCCCCCUUGGGCAGGGGAAGCAGGACUCCGGGCCCUUGAGUCGUGGUUUCCUGGUCAUGACCGGGCAGAGCUAAUAGCAGUAGAACAGCUCCCAGCAACAGCAUCCUGAGCCCUGGAAUCCACAUGUGCACUGUCAGCCAUGGAGAGACAGACCCCACACACACACCCAGUUGGGACCUACAAAGGACUCCGUCCAUCUCAGCAGAGUCUACUUCUAGGAGCUGCUUUCUAAGUAUUCAACUUUUCCAGGAAGACUUUUCUGAAUAUUGCAGCCCACCUUGAUCUCUUUCUGCCCUGAAAUCUGUAAUACUUAGCAUUAUUCCCUGUGUGUAGUCUCCUUUCCUCACCAAGAUUAUGAAUUCAGUGAUUGCACAGAUGACACUCCUCUAAUUUUCCCAUGUCUGAGCACAGGACCAAGCACAGGGAAAGCUCCAAGAGUCGACUUGCCAAGAAUCCAUCCUUGGGUUUCCCAAGUACGAUGACACAGAUUGCUCCAUUCAAUGCUAACCAGCUUCUCUCCUCUGGCUCCUUUCUUCUUUUUCUUUCCCCCCUUCUCUCUCAUUUUCUGUGUCUAUUCCUCCUUCUUACUCUCUCAUUCUCUUUCUUCCUCUACCCCUCUCCUGGGGCACAUGUUUGACUAUUGGGUAUAUUACAUUUGCACACAUGCACACACACAAACACACACAGAGAAAAAGAGAGAGAGAGGGAGGGAGAGACUCACCUUGUGUUAAGCAGACAACGAGAGACACAUCAUCCCAUGAACAUAUCCCCUGGCCCUUUGUUUGCCUGAGCCAUCUUUAGCUGCCCCUCCUCCCCUGUCUAAUCUCUAUUCAGCUUUCAGGACCCAGUUUGGAUGUCAUCUGUUUCAAGAAGUCCUCCUUGUUCUCCAUCUCACUCCUUGGCUGGUUCUUUCCCCUCUGUGUUUCUCCAGUGCCCUGGUAAUAUGGUUUGGGUCUGUGUCCCCACCCAAAUAGCACGUCGACAUGUGUUGGAGAAGGGGCCUGGUAGGAGGUGACUGAAUCAUGGAGGCAGACUUAUCCCUUGCUGUUCUCAUGAUAGUAGGUGAAUUCUCACAAGAUCUGGUUGAAAGUGUGUAGCACUUCCCCUAUAUUCUCUCUCUCUCUCUUUCUCUCUCUCUCUCCUGCUGCUGUGUGAUGUGCUUGCUUCCCCUUCGCUCUUUCUUCCACCAUGAUUGUAAGUUUUCUGAGGCCUCCCCAGCCAUGCUUCCUGUACAGCCUGUGGAACUGUGAGUCAAUUAAACCUCUUUUCUUUAUAAA

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