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Homo sapiens (human) Pvt1 oncogene (PVT1) URS00008E3A67_9606

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PVT1: PVT1 is a long non-coding RNA (lncRNA) that has been extensively studied in various types of cancer, including sarcoma, gallbladder cancer, glioma, liver cancer, and lung cancer [PMC6775530] [PMC10086562] [PMC8366097] [PMC8308086] [PMC8100187]. In gallbladder cancer, PVT1 is upregulated and associated with malignancy and worse overall survival [PMC8366097]. PVT1 has been shown to modulate glucose metabolism in gallbladder cancer by competitively binding to miR-143 and regulating HK2 expression [PMC10086562]. Additionally, PVT1 has been implicated in the regulation of ferroptosis in various cancers including glioma and liver cancer through the modulation of TFR1, TP53, and GPX4 expression via miR-214-mediated pathways [PMC9729877] [PMC9334798] [PMC9433379] [PMC9019694]. In lung cancer, PVT1 has been found to promote proliferation, migration, angiogenesis through its interaction with ALKBH5 and regulation of stability in lung cancer cells. Silencing ALKBH5 decreased the expression levels of PVT1 in lung cancer cells and suppressed tumor growth in zebrafish xenografts models. Furthermore, curcumin treatment has been shown to sensitize pancreatic cancer cells to gemcitabine by downregulating EZH2 expression as a subunit of the polycomb repressive complex 2 (PRC2) along with its associated lncRNA PVT1. This inhibition restored gemcitabine activity in pancreatic cancer cells that were resistant to treatment. Overall, these findings highlight the diverse roles of PVT1 as a modulator of glucose metabolism and ferroptosis as well as its potential as a therapeutic target in various types of cancer [PMC9664734] [PMC8810122] [PMC6959860] [PMC9774417].

Genome locations

Gene Ontology annotations

Sequence

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CUCCGGGCAGAGCGCGUGUGGCGGCCGAGCACAUGGGCCCGCGGGCCGGGCGGGCUCGGGGCGGCCGGGACGAGGAGGGGCGACGACGAGCUGCGAGCAAAGAUGUGCCCCGGGACCCCCGGCACCUUCCAGUGGAUUUCCUUGCGGAAAGGAUGUUGGCGGUCCCUGUGACCUGUGGAGACACGGCCAGAUCUGCCCUCCAGCCUGAUCUUUUGGCCAGAAGGAGAUUAAAAAGAUGCCCCUCAAGAUGGCUGUGCCUGUCAGCUGCAUGGAGCUUCGUUCAAGUAUUUUCUGAGCCUGAUGGAUUUACAGUGAUCUUCAGUGGUCUGGGGAAUAACGCUGGUGGAACCAUGCACUGGAAUGACACACGCCCGGCACAUUUCAGGAUACUAAAAGUGGUUUUAAGGGAGGCUGUGGCUGAAUGCCUCAUGGAUUCUUACAGCUUGGAUGUCCAUGGGGGACGAAGGACUGCAGCUGGCUGAGAGGGUUGAGAUCUCUGUUUACUUAGAUCUCUGCCAACUUCCUUUGGGUCUCCCUAUGGAAUGUAAGACCCCGACUCUUCCUGGUGAAGCAUCUGAUGCACGUUCCAUCCGGCGCUCAGCUGGGCUUGAGCUGACCAUACUCCCUGGAGCCUUCUCCCGAGGUGCGCGGGUGACCUUGGCACAUACAGCCAUCAUGAUGGUACUUUAAGUGGAGGCUGAAUCAUCUCCCCUUUGAGCUGCUUGGCACGUGGCUCCCUUGGUGUUCCCCUUUUACUGCCAGGACACUGAGAUUUGGAGAGAGUCUCACUCUGUGGUCCAGGCUGAAGUACAGUGGCAUGAUCCCAGGUCACUGCAACCCCCACCUCCCGGGUUCAAGUGAUCCUCCUGCCUCAGCCUCCCGAGUAGCUGGUAUUACAGGCGUGUGCCACAAAGCCUGGCUAAGUUUUGUAUUUUUAGUAGAGACGGGGUUUCACCAUGUUGGCCAGGUUGGUCUCGAACUCCUGACCUCAAGUGAUCCACUCACUUUGGCCUUUCAACGUGCUGGGAUUACAGGCGAGAGUCACCGCACCCGGACGACUCUGACAUUUUUGAAGAGUCCAGAAUCCUGUUACACCUGGGAUUUAGGCACUUUCAAUCUGAAAAAAUACAUAUCCUUUCAGCACUCUGGACGGACUUGAGAACUGUCCUUACGUGACCUAAAGCUGGAGUAUUUUGAGAUUGGAGAAUUAAGAGCCAGUCUUGGUGCUCUGUGUUCACCUGGUUCAUCUGAGGAGCUGCAUCUACCCUGCCCAUGCCAUAGAUCCUGCCCUGUUUGCUUCUCCUGUUGCUGCUAGUGGACAUGAGAAGGACAGAAUAACGGGCUCCCAGAUUCACAAGCCCCACCAAGAGGAUCACCCCAGGAACGCUUGGAGGCUGAGGAGUUCACUGAGGCUACUGCAUCUUGAGACUCAGGAUGAAGACCCAGCUUGGGGCUGUCAAAGAGGCCUGAAGAGGCAGAACACCCCAGAGGAGCCUGGGGCCACCACCCAGCAUCACUGUGGGAAAACGGCAGCAGGAAAUGUCCUCUCGCCUGCGUGCUCCACCUCGGUCCACGCCUUCCCUCCUUCUGGAAGCCUUGCCUGACCACUGGCCUGCCCCUUCUAUGGGAAUCACUACUGACCUUGCAGCUUAUUAUAGACUUAUAUGUUUUUUGCAUGUCUGACACCCAUGACUCCACCUGGACCUUAUGGCUCCACCCAGAAGCAAUUCAGCCCAACAGGAGGACAGCUUCAACCCAUUACGAUUUCAUCUCUGCCCCAACCACUCAGCAGCAAGCACCUGUUACCUGUCCACCCCCACCCCUUCCCCCAAACUGCCUUUGAAAAAUCCCUAACCUAUGAGCUUUGAAUAAGAUGAGUACGAACUUCAUCGCCCACGUGGCGUGGCCGGCCUCGUGUCUAUUAAAUUCUUUUUCUACUAAAAAAAAAAAAAAAAAA

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Publications