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Homo sapiens (human) prostate cancer associated 3 (PCA3) URS00008E3A1F_9606

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PCA3: PCA3, which stands for prostate cancer antigen 3, is an established urine RNA biomarker for prostate cancer diagnosis [PMC10151018]. It has been found that platelets isolated from glioma and prostate cancer patients contain cancer-related RNA biomarkers EGFRvIII and PCA3, respectively [PMC8936192]. PCA3 is an antisense intronic long noncoding RNA (lncRNA) that binds to the PRUNE2 pre-mRNA in prostate cancer cell lines, regulating the expression of PRUNE2 at both mRNA and protein levels [PMC5715103]. Platelets inherit various types of RNAs from the megakaryocyte, including mRNA, lncRNAs, miRNAs, tRNAs, and circRNAs [PMC8351883]. Tumor microvesicles or exosomes are thought to be involved in the transfer of markers like EGFRvIII and PCA3 into platelets [PMC8351883]. However, it is still unclear how these microvesicles fuse with platelets and unload their cargo or whether these transcripts are translated into functional proteins [PMC8351883]. Studies have shown that miRNAs in urine have diagnostic potential for prostate cancer detection and their diagnostic value appears to be greater than that of PCA3 [PMC4955179] [PMC6316409] [PMC4955179] [PMC4955179] . Additionally, combining urinary miR-187 levels with other predictive factors including serum PSA and urinary PCA3 has been shown to be superior for predicting disease progression compared to PSA alone . The combination of urinary PCA3 with fusion gene TMPRSS2-ERG has also been found to increase specificity in prostate cancer diagnosis compared with serum PSA alone .

Genome locations

Gene Ontology annotations

Sequence

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ACAGAAGAAAUAGCAAGUGCCGAGAAGCUGGCAUCAGAAAAACAGAGGGGAGAUUUGUGUGGCUGCAGCCGAGGGAGACCAGGAAGAUCUGCAUGGUGGGAAGGACCUGAUGAUACAGAGGUGAGAAAUAAGAAAGGCUGCUGACUUUACCAUCUGAGGCCACACAUCUGCUGAAAUGGAGAUAAUUAACAUCACUAGAAACAGCAAGAUGACAAUAUAAUGUCUAAGUAGUGACAUGUUUUUGCACAUUUCCAGCCCCUUUAAAUAUCCACACACACAGGAAGCACAAAAGGAAGCACAGAGAUCCCUGGGAGAAAUGCCCGGCCGCCAUCUUGGGUCAUCGAUGAGCCUCGCCCUGUGCCUGGUCCCGCUUGUGAGGGAAGGACAUUAGAAAAUGAAUUGAUGUGUUCCUUAAAGGAUGGGCAGGAAAACAGAUCCUGUUGUGGAUAUUUAUUUGAACGGGAUUACAGAUUUGAAAUGAAGUCACAAAGUGAGCAUUACCAAUGAGAGGAAAACAGACGAGAAAAUCUUGAUGGCUUCACAAGACAUGCAACAAACAAAAUGGAAUACUGUGAUGACAUGAGGCAGCCAAGCUGGGGAGGAGAUAACCACGGGGCAGAGGGUCAGGAUUCUGGCCCUGCUGCCUAAACUGUGCGUUCAUAACCAAAUCAUUUCAUAUUUCUAACCCUCAAAACAAAGCUGUUGUAAUAUCUGAUCUCUACGGUUCCUUCUGGGCCCAACAUUCUCCAUAUAUCCAGCCACACUCAUUUUUAAUAUUUAGUUCCCAGAUCUGUACUGUGACCUUUCUACACUGUAGAAUAACAUUACUCAUUUUGUUCAAAGACCCUUCGUGUUGCUGCCUAAUAUGUAGCUGACUGUUUUUCCUAAGGAGUGUUCUGGCCCAGGGGAUCUGUGAACAGGCUGGGAAGCAUCUCAAGAUCUUUCCAGGGUUAUACUUACUAGCACACAGCAUGAUCAUUACGGAGUGAAUUAUCUAAUCAACAUCAUCCUCAGUGUCUUUGCCCAUACUGAAAUUCAUUUCCCACUUUUGUGCCCAUUCUCAAGACCUCAAAAUGUCAUUCCAUUAAUAUCACAGGAUUAACUUUUUUUUUUAACCUGGAAGAAUUCAAUGUUACAUGCAGCUAUGGGAAUUUAAUUACAUAUUUUGUUUUCCAGUGCAAAGAUGACUAAGUCCUUUAUCCCUCCCCUUUGUUUGAUUUUUUUUCCAGUAUAAAGUUAAAAUGCUUAGCCUUGUACUGAGGCUGUAUACAGCCACAGCCUCUCCCCAUCCCUCCAGCCUUAUCUGUCAUCACCAUCAACCCCUCCCAUGCACCUAAACAAAAUCUAACUUGUAAUUCCUUGAACAUGUCAGGCAUACAUUAUUCCUUCUGCCUGAGAAGCUCUUCCUUGUCUCUUAAAUCUAGAAUGAUGUAAAGUUUUGAAUAAGUUGACUAUCUUACUUCAUGCAAAGAAGGGACACAUAUGAGAUUCAUCAUCACAUGAGACAGCAAAUACUAAAAGUGUAAUUUGAUUAUAAGAGUUUAGAUAAAUAUAUGAAAUGCAAGAGCCACAGAGGGAAUGUUUAUGGGGCACGUUUGUAAGCCUGGGAUGUGAAGCAAAGGCAGGGAACCUCAUAGUAUCUUAUAUAAUAUACUUCAUUUCUCUAUCUCUAUCACAAUAUCCAACAAGCUUUUCACAGAAUUCAUGCAGUGCAAAUCCCCAAAGGUAACCUUUAUCCAUUUCAUGGUGAGUGCGCUUUAGAAUUUUGGCAAAUCAUACUGGUCACUUAUCUCAACUUUGAGAUGUGUUUGUCCUUGUAGUUAAUUGAAAGAAAUAGGGCACUCUUGUGAGCCACUUUAGGGUUCACUCCUGGCAAUAAAGAAUUUACAAAGAGCUACUCAGGACCAGUUGUUAAGAGCUCUGUGUGUGUGUGUGUGUGUGUGAGUGUACAUGCCAAAGUGUGCCUCUCUCUCUUUGACCCAUUAUUUCAGACUUAAAAACAAGCAUGUUUUCAAAUGGCACUAUGAGCUGCCAAUGAUGUAUCACCACCAUAUCUCAUUAUUCUCCAGUAAAUGUGAUAAUAAUGUCAUCUGUUAACAUAAAAAAAGUUUGACUUCACAAAAGCAGCUGGAAAUGGACAACCACAAUAUGCAUAAAUCUAACUCCUACCAUCAGCUACACACUGCUUGACAUAUAUUGUUAGAAGCACCUCGCAUUUGUGGGUUCUCUUAAGCAAAAUACUUGCAUUAGGUCUCAGCUGGGGCUGUGCAUCAGGCGGUUUGAGAAAUAUUCAAUUCUCAGCAGAAGCCAGAAUUUGAAUUCCCUCAUCUUUUAGGAAUCAUUUACCAGGUUUGGAGAGGAUUCAGACAGCUCAGGUGCUUUCACUAAUGUCUCUGAACUUCUGUCCCUCUUUGUGUUCAUGGAUAGUCCAAUAAAUAAUGUUAUCUUUGAACUGAUGCUCAUAGGAGAGAAUAUAAGAACUCUGAGUGAUAUCAACAUUAGGGAUUCAAAGAAAUAUUAGAUUUAAGCUCACACUGGUCAAAAGGAACCAAGAUACAAAGAACUCUGAGCUGUCAUCGUCCCCAUCUCUGUGAGCCACAACCAACAGCAGGACCCAACGCAUGUCUGAGAUCCUUAAAUCAAGGAAACCAGUGUCAUGAGUUGAAUUCUCCUAUUAUGGAUGCUAGCUUCUGGCCAUCUCUGGCUCUCCUCUUGACACAUAUUAGCUUCUAGCCUUUGCUUCCACGACUUUUAUCUUUUCUCCAACACAUCGCUUACCAAUCCUCUCUCUGCUCUGUUGCUUUGGACUUCCCCACAAGAAUUUCAACGACUCUCAAGUCUUUUCUUCCAUCCCCACCACUAACCUGAAUGCCUAGACCCUUAUUUUUAUUAAUUUCCAAUAGAUGCUGCCUAUGGGCUAUAUUGCUUUAGAUGAACAUUAGAUAUUUAAAGCUCAAGAGGUUCAAAAUCCAACUCAUUAUCUUCUCUUUCUUUCACCUCCCUGCUCCUCUCCCUAUAUUACUGAUUGCACUGAACAGCAUGGUCCCCAAUGUAGCCAUGCAAAUGAGAAACCCAGUGGCUCCUUGUGGUACAUGCAUGCAAGACUGCUGAAGCCAGAAGGAUGACUGAUUACGCCUCAUGGGUGGAGGGGACCACUCCUGGGCCUUCGUGAUUGUCAGGAGCAAGACCUGAGAUGCUCCCUGCCUUCAGUGUCCUCUGCAUCUCCCCUUUCUAAUGAAGAUCCAUAGAAUUUGCUACAUUUGAGAAUUCCAAUUAGGAACUCACAUGUUUUAUCUGCCCUAUCAAUUUUUUAAACUUGCUGAAAAUUAAGUUUUUUCAAAAUCUGUCCUUGUAAAUUACUUUUUCUUACAGUGUCUUGGCAUACUAUAUCAACUUUGAUUCUUUGUUACAACUUUUCUUACUCUUUUAUCACCAAAGUGGCUUUUAUUCUCUUUAUUAUUAUUAUUUUCUUUUACUACUAUAUUACGUUGUUAUUAUUUUGUUCUCUAUAGUAUCAAUUUAUUUGAUUUAGUUUCAAUUUAUUUUUAUUGCUGACUUUUAAAAUAAGUGAUUCGGGGGGUGGGAGAACAGGGGAGGGAGAGCAUUAGGACAAAUACCUAAUGCAUGUGGGACUUAAAACCUAGAUGAUGGGUUGAUAGGUGCAGCAAACCACUAUGGCACACGUAUACCUGUGUAACAAACCUACACAUUCUGCACAUGUAUCCCAGAACGUAAAGUAAAAUUUAAAAAAAAGUGA

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Publications