DANT2: DANT2 is a long non-coding RNA (lncRNA) expressed from the active X chromosome [PMC9588035]. In a study, DANT2 was identified as one of the hub genes in an immune-related ceRNA sub-network based on E6 splicing [PMC9796994]. Another study found that DANT2, along with LINC01711 and LINC00922, was significantly upregulated in ovarian cancer tissues and correlated with poor prognosis [PMC8194245]. However, the expression of DANT2 was inconsistent across different ovarian cancer cell lines [PMC8194245]. In human X chromosome inactivation (XCI), DANT2 is transcribed from the DXZ4 locus along with DANT1 [PMC8662614]. In breast cancer cells, treatment with PTS resulted in hypermethylation and silencing of the DANT2 enhancer [PMC9793217]. The enhancer activity of the DANT2 promoter has been previously characterized [PMC6088404]. Additionally, DANT2 has been identified as a putative oncogene and is associated with Xi-biased bindings of certain transcription factors on the inactive X chromosome [PMC8388921] [PMC5114649]. Overall, DANT2 is an lncRNA expressed from the active X chromosome that has been implicated in immune-related ceRNA networks, ovarian cancer prognosis, breast cancer gene silencing, and Xi-biased transcription factor bindings on the inactive X chromosome.