v24

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Homo sapiens (human) T helper type 2 locus control region associated RNA (TH2LCRR) URS00008E39C6_9606

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TH2LCRR: TH2LCRR is a long non-coding RNA (lncRNA) that is specifically expressed in TH2 cells and is involved in TH2 polarization and chromatin remodeling at IL4, IL5, and IL13 genomic loci [PMC6215836]. It has been found to be associated with worse recurrence-free survival (RFS) in hepatocellular carcinoma (HCC) patients [PMC9080350]. Loss of TH2LCRR can downregulate human Th2-type cytokines [PMC9972402]. Additionally, TH2LCRR has been identified as a common variant associated with eczema [PMC8595373]. Depletion of TH2LCRR can abrogate the expression of IL4, IL5, and IL13 in human T cell cultures [PMC5842023]. The mechanism of action for TH2LCRR is not fully understood, but it has been shown to bind the MLL H3K4-methyltransferase complex and contribute to chromatin remodeling at specific gene loci [PMC6215836]. It is not known if TH2LCRR forms a DNA-RNA hybrid, but it is a possibility [PMC6215836]. The association between specific single nucleotide polymorphisms (SNPs) at the RAD50 and TH2LCRR loci with atopic dermatitis (AD) has been reported in previous studies, although there have been conflicting results due to sample size limitations and different genetic backgrounds among populations [PMC6021591].

Genome locations

Gene Ontology annotations

Sequence

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UUUUCUCUGGAAGAAAAAUUUAAAAGUAAUAAAGACAAACUACAGUUACUUGGGUGAGUUGGCUCCCCAGGCUUUUGAGAUACCUGCCUUUUGUCCAGCACUGCAUCGUCCUCGCAUAUCCAAGGCUGUGUCUCCCUUCAGCAUCACCACUCGGCUUUUAGCAGACUGAAGCCAUGGUUUUUAGUUUUGUCUCUAGUGAUGAGCAGAAAAGAGGGAUGAGGAAGAGGCUUUACUGGUCCAACCAGAAAGAGAAGCUAAGAACCCAUGACUGGAUUCUCUCCCUUGGACACCCCACAGACCAAUAUCUCACCUUCCAGGAGAAGACCCUUCCAGCUCUUGCUUCUUUAAACCUAUUAACUUAGUUUUCUUUAGCUAGACUCCCAAACAUCAGCUUUUACAAUUCAGCCUAUGGUUCAAUCACUAUGGCAAGAUAAACAUUUGUUUAGGUGUGAAACAAAAAAAAAAAAAAA

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Publications