SNORD14: SNORD14 is a small nucleolar RNA (snoRNA) that is present in humans, mice, and rats and is localized to the introns of the hsc70 gene [PMC7277114]. While most snoRNAs are not essential for cell viability, SNORD14, along with SNORD3 (U3), SNORD118, and SNORA73, plays a direct role in pre-rRNA cleavage and is essential for cell viability [PMC8508363]. Differential processing of SNORD14 has been observed in different species, with variations in processing profiles at the 5' and 3' ends [PMC6511844]. The structure of SNORD14 has proven to be challenging to solve using available tools [PMC5674771]. SNORD14 has been found to be highly significant in relation to heat stress [PMC9021797]. In a study comparing gene expression profiles, SNORD14 was found to be increased by more than two-fold in DHA-treated samples compared to the control [PMC5679375]. In relation to ribosomal RNA modifications, snoRNAs such as SNORD100 (HBII-439), SNORD68 (HBII-202), and SNORD56 (U56) guide modifications at or near DDX21 crosslinking sites in the 18S rRNA sequence along with SNORD14 (U14) [PMC4288182]. The snoRA7 family contains 10 genes similar to the snoR71 family, while the remaining families have fewer genes per family including the SNORD14 family with 10 genes as well [PMC3886394].