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Homo sapiens (human) NF-kappaB interacting lncRNA (NKILA) URS00008120E1_9606

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NKILA: NKILA is a long non-coding RNA (lncRNA) that has been studied in various contexts. However, there is currently no evidence to suggest that acute hypoxia can significantly upregulate NKILA expression in gliomas [PMC7206073]. NKILA has been shown to facilitate the osteogenesis of mesenchymal stem cells (MSCs) through two critical signaling pathways [PMC6933397]. It has also been identified as an immunogenic lncRNA that can be targeted for cancer immunotherapy [PMC9454129]. NKILA can reduce IκB phosphorylation and NF-κB activation, inhibiting p65 nuclear translocation and sensitizing laryngeal cancer cells to radiotherapy [PMC5943486]. Inhibition of NKILA has been found to decrease the apoptosis rate and respiratory burst intensity of neutrophils infected with hypervirulent Klebsiella pneumoniae (hvKP) in vitro [PMC8553458]. Overexpression of NKILA in astrocytes has been shown to significantly increase its expression, validating successful infection efficiency [PMC8034961]. NKILA can bind to NF-κB and repress its activity on downstream anti-apoptotic target genes, leading to apoptosis of effector CD8+ T cells and escape of tumor cells from cytotoxicity [PMC8699382]. Lentivirus expressing shRNAs or the open reading frame of NKILA have been obtained for experimental purposes [PMC5811242]. The expression levels of tissue miR103, miR107, and NKILA have been analyzed as potential biomarkers in colorectal cancer patients using ROC curves [PMC7306231].\

Genome locations

Gene Ontology annotations

Sequence

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AGACCCGGCACCCGCGCAACGGAGGAGGGGCGCUGUGCCCUCUCCCCAACGGCGGUCAGCUUGGAACGCCUGCCCGGCGCACGCCCGGGGCCGGGGAGCCGAACUCGGUGCCAGCCGCACCCGGGCGGGUUGCUGGUGCGCCCUCCCCUCGCCCCCGUCCCUGGGGUCCUUGACCCAGGCUCUUGGGGCUAGCCUAUCUUCUGAGGAGCACAAGGUCCCUGGGGGCUCAGGGAAGAGAAAUUGGAGAAAGGGGGAGGAAGCCCCCAAGAUGGAUCACCCAUUGCCUGGUUUCGCAGGAGACUGUCCGCCUUCAGUUCUCCAGCAGCUCGGGGAUCAUGGCCCACUGAACCCCCAAGCGCUUUCACCCGAACCCAAGGAGGACGACCAGGAAAGACGGGAACUCGCGUAGACACGCCCGGAAGCCCUUGUCAUGUAAAUAGCUGUCGGGGACUGGUGUAUUGUCGCCGCCCCAGCCGGCGGGACCUGGGGCGAAUCCACACCCAUUGUCUGCUGCCCAAGGGGCCUCCGGCUGGGGGGCGCGGCUGCGGAGUUCAAAAGGGGUAUGAGCAGGAGGGGUGUACUUUUAGUUCAUUAAGUUUUAAUUACAGGAGUGCUACAAGAACACAUUCUUCAGGUUUAAAAAGAUAUUAAAAUAUUACAUAAGAGACCUCCCCUCCCUGGCCCACCUCCAGCCUCUUAAAAAUUUAGUGUGUCGCCUUUUAGACACUUUCUCAAAGCUUCACUUAUUUAACAGGCACUUAAGGAGCACCUACCUGUGCCAGAAACUCUCCAAAUAUUAACUCAACCUGACACCGACUCAGUGUGGCCGAAUAUUACUCUCCCCAUUUUACAGAGCGGGCAGCUGGUCAAGGAAGUCGCUUGUUGAAAGUCACACAGUGGUGGAGCCUGUGUGCCAACCCAGGACCCUGGGGAGCUGCCUCCCCCUCUCCCACGUAGUCCUGAUUCUUUAAGUGUCCACAUAUUCCUGUAAUGCCUGGAGUUUCAGUAAUUAGCAGGGACUUAGUGUGUUCAGAGAAAAAAAAAGCUUUUAAAAAUUAUUGUUACUGUGUUUGUAACAGUUUGGAUAGAGAAGGAAAAGCUGGAAUUUGGGAAGUGAAGGUGGCCUCGGGGUAGAACUUACCUAGACCAGAGCGAAUUCAUCCUGAAGAACUCAGAGAAAGCCGGUGCAGGAAGUGGGUUCCCGCUCUCCCUGCACAGGCACAGUGAUGCUGCCAGAGCUCUCCCAGAAAGACCAGGAGGCUUGUUCUGGAGAAGUCAAGCCCAGGGAUGUGGCUCAGGCUGGUCCAAGCUCUUUGGAGGAGUCCAAGCGUGCCCAGCCCAGAGGGAGGUUCAGAGGCACUGACCGUCUUCUGUUUGGGAGGAGAAGCUCACUCUUGGAGCCACAGCCAGCACUAGGUCAGGACCCAGGCCCCGGCCCAGGAGUGGGGCAAUACCCAGCGUCUACCCCAGAUGGCACCCUGCUGUGAACUGGGCGCCCUCAGCCCCUGCCUUGAGGAAGGGGCAAUACCACCAGCGUGUCUUUUAUCAGGGAAGAUAUUGCUGCAGUUUGGCCGCUGCAACUUAAGAGAAAAGCUAAGGGGUCCCCCAGCAUCCCUUGGGGUGCCACUGCAAAUACUGGCUGGGCCUGGAGAUGACCUGGGUCCCAUUCACUUCCUAGGGUGAAGGAGGUCAUCAUUACCACCCCUGCUUUCAGCCAUUUCUUCAUUCAUUCAAUCAACAAACUGGCUGAGCUGCAACCCUGAGCCGGGGAAUUCAGCCACUCCAGACACAGCCCCUGCCCUCCGGGAAGUCUCGGGAGACCUGGCUAGUCUGGCUGGGAGAAGUCACACGUUGAUUGUCUUGGAAGUGAGAUGGCAUUUACACAAUGGAGGCUGCACUGCCAGCAGGCAAAAAUAACCAGUUAAUUCAGUGGCUUAAAGAAACCAAACCUACCCACAACGCUUGACCUCCCAUUGAUCCAUCUGCGACACCGGCAGUGGCUACCAUUUAUUGAGUGCUGAUGGUGUCACCUGGGAUUGACUUAGUGGUCUCUGGCGCUAGUUCCGAAGUUGAUUCUGUCUGGAGAGCUUAAUGCAGUGUUCAGACCUCAGGGUCCGAACCUGAGGGUCACCCAAAGAUGAGUGGGACAUAGCUGUGUGACCUCGGCUGAGUGCUUUCACCUCUCCAACCUCAGUUUCCUCUUCUGCAAAAUGGGGUGGCUUCAUGGCACCUUCACGUGGUGUGAUUGCGAGGAAUGAAGGGAUCGAUGCCUUGCAAGUAGAGGAGAAGGGGCCGGAUACAUCUUAGUUGUUAUGUUAUUUAAUCAUCUUGGCAACCCCGGGAGGGAGGAACCACUAUCAUUUUAUUUUCCAUUUUGCAGUUGAGGACAAUGAUGAUUCCAGCACAGACAGGGCCCCUGACGGGGCAGUAGGAAAGGAGAAUUGCUUUGGAAGGAGCAUAGGCUGGACUGCCAGCACUCAUAGGAGGCUUCGUGUGUGCCCAGGACUGCGAGAAUUAAAUACAGGACACCCAGUUCAGUUUGAAUUUCAGAUAAACUAUGAAUAAUGAUUAGUGUAAGUAUAUCUCAAUUUAACUGGAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications