v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) atherosclerotic plaque pathogenesis associated transcript (APPAT) URS00007E40C8_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

APPAT: Major downregulation of atherosclerotic plaque pathogenesis-associated transcript (APPAT) has been found in coronary artery samples from patients with severe stenosis, and the level of circulating APPAT correlates negatively with that of circulating miR-647, which has been identified as a candidate target of APPAT [PMC6964217]. Thus, dynamic changes in the level of APPAT might indicate disease stage in clinical diagnostic applications [PMC6964217]. About 12 LncRNAs were up-regulated and 4 (GAS5, ZFAS1, APPAT and ANRIL) were down-regulated [PMC6435511]. The clinical significance of the lncRNA, APPAT, in the diagnosis and progression of AS has been illustrated [PMC10013137]. The dynamical alteration of APPAT might provide potential value in the development of disease in clinical diagnosis [PMC5775756]. The expressions of APPAT and its targeting miR-647 were detectable in circulating blood and pathological tissue both [PMC5775756]. Comparison between APPAT and cTnI showed no significant difference (P = 0.4678) [PMC5775756]. The distribution and subcellular location of APPAT was determined from samples collected from coronary artery tissue [PMC5775756]. Unlike mitochondrial genome originated lncRNAs which were mainly expressed in heart ,APPAT gene was localized on autosomal (chromosomes 2) and should initially generated in nucleus but functioned in cytoplasm [PMC5775756].

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
GCAUGGGAUGCACAAAUGGAAAUUCCACUGGGUCUGCAGCUCACACAUAGGCAUGACCAGCAUAGAGAUAGAGAGGCCCCAGUGCUGCUGAGUAACUGUGAUUCCCCAGGUGAUGGCAUCAGCUGAGAAGGGAAGGAAGCCCAUGAGAGGACACUGAAGAAGGAGUGAGCAGACAAUAAGAAGCCCACAGAAGACAGAGAAGGAACAACUAGAGGGAGAAGCCAAGGCAGGCGUGUGUGUUUCUCCACAGACACUACCCAAAGCAGUGCUUCACUACAGUGGCAGACAGACCUGAAAAUUUUCAUCUGAAGCAGCAGAGUGAACUGCAGAGGCAGGUCACCAACCAGUGUGGAGGCUAAAAGCGGGCCUCUUUGGGGAUUCCAGGUGGAAGUGUUGGACAUCUGUAGUAUUCCUGGUCUCGAAUCAUCCUGAUAUUCUUCAUUUUGUUAUUCACAUUGGACUAGGAGAUAGAAUCUCACUAUGUUGACCAGGCUGGUCUUGAACUCUUGGCACCCAAGCGAUCCUUUUGCCUGGAAUCCCAAAGUGUCAGAUUUACUGAAGAAUAUUUCAUUGUAAUUACUUUUUAUACUUUAUAGGUCAAGAGCUCUGUUUUAAAUACAAAAUUUAUUGAAUAUACUUUUUCAAACAAAGUUUCAUGUUCUAAUCAUUGUCUGAUUUCAGCAUUAAAUGAAACACAGUAAAGAAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications