v24

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Homo sapiens (human) lncRNA negative regulator of antiviral signaling (LNCATV) URS00007E4015_9606

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LNCATV: LNCATV is a human-specific long non-coding RNA (lncRNA) that is upregulated by type I and type III interferon treatment as well as viral infections with several viruses, including hepatitis C virus (HCV), vesicular stomatitis virus (VSV), and Sendai virus (SeV) [PMC8914027] [PMC7503479] [PMC6652118]. It acts as a negative regulator of the RIG-I antiviral signaling pathway by directly interacting with RIG-I, leading to the repression of RIG-I antiviral signaling and a defective interferon response [PMC7503479]. LNCATV is predominantly enriched in the cytosol and is required for multiple virus infections, potentially using a universal regulatory mode [PMC6658999] [PMC6652118]. Knockdown of LNCATV enhances the induction of interferon-beta (IFNβ) and interferon-stimulated genes (ISGs), leading to a stronger antiviral response against viruses such as Newcastle disease virus (NDV) and Zika virus (ZIKV) [PMC6658999]. LNCATV also inhibits the production of type I interferons and inflammatory factors, preventing excessive activation of signaling pathways [PMC9682092]. It associates with full-length RIG-I, inhibits phosphorylation of TBK1, STAT1, and IRF3, and antagonizes virus-stimulated phosphorylation events in host cells [PMC6658999] [PMC9682092]. LNCATV acts as a negative regulator of innate immune responses by suppressing type I interferon production and host antiviral defense mechanisms in human cells infected with RNA viruses [PMC8420315] [PMC8430513].

Genome locations

Gene Ontology annotations

Sequence

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AACCUCAUAGGUGGUUUGGGAUGUCUUUUGGCUGUGCUUAAAAAUUUCCAACAGAUUUGCUACACAUCUUAGGAUAAAUAUGUUUCCUGUGAAUUGUGAUGAUUUCUUACAGUACAUUUGCAAGCAUGUGUAUGCAUCUGCAGGAAACAUAGCCUGGCUCUGUGAAGGAAUACUGCUGUGACCGCAAAACUGUUUCUGUAGAAUUUUCUCCGGUGUGGUCAUCCUGCCUUCAGAGGUUUCUCCAGGACGUCACCUGUAUGAGGUACACAGUGUGAUGACACACUCUGUGCUUUUCCUACUUGUGUCCACGGCUCAAGCCUGGAAGAAGCCUUAGGACGUGGGGGAAAUGUCUAACGUGGAGUCCACCUGCUGAGCAGGACCGGGUGUGAAGGAAGAAGCUUUGUUCUGAUUCCUCAUGGCCCAGCCACCCCUCGCCUGAGCUGAGCCUGGCCACAGGGCCCGCCUGCAGGAAGGGCUGGCCCAUGGCUUCACACUGGGCUCAGGCUGCGCUAAGAGCCCCGGGUGAGGACCUCCAAGCCCAGGAAGCCUCAGUUGGCCAAAGUGCUAGAUGCGUGUGGUCUGCUUUCAUCCCCGCUUCCCUCAGAGCUUGCAUUUUCCAAAUUCAAGAGAGGCUCCACCUUCAAGAAGACCGGCCUGUCCCUGUUAUUUAUGUGUCCCCCUACCAUAUCUCCCUUUGUUCUGCAGAGCGGCCAUACCUGCCAGCAGCCUGCUCUCCCGGCCAUGCUGCGGUUCACAAAAGUCCAGCAUUUGGCUAGCUUCCUGGGGGAAUGAAUCUUUCAGAGCCAAACUAAUGCUAUGCAUGCAGCUUAUGAUUUUUUUUUUUUUGUCUUCAACAAAGUGAAUACUUACUUUUUUUUUGCUCUUUAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications