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Homo sapiens (human) BACE1 antisense RNA (BACE1-AS) URS00007E3977_9606

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BACE1-AS: BACE1-AS is a long non-coding RNA (lncRNA) that has been studied in various contexts. It has been shown that BACE1-AS can physically bind to HIF-1α, leading to the stabilization of BACE1 mRNA [PMC7274476]. BACE1-AS has been found to be highly expressed in endothelial cells derived from atherosclerotic plaques [PMC9626031]. In MPP+-induced SH-SY5Y cells, the overexpression of BACE1-AS and underexpression of miR-214-3p were observed, and down-regulation of miR-214-3p reversed the effects of BACE1-AS-siRNA on these cells [PMC9208522]. Increased expressions of KDM4A-AS1, BACE1-AS, and NRAV were associated with worse prognosis in HCC patients [PMC8854774]. In Alzheimer's disease (AD) patients, BACE1-AS is upregulated in plasma and may serve as a potential blood-based biomarker for AD development [PMC9441681]. The expression level of BACE1-AS is increased in AD patients compared to controls [PMC8391852]. It has been demonstrated that plasma exosomal levels of BACE1-AS could serve as a biomarker for AD [PMC7765627]. Furthermore, it has been shown that BACE1 anti-sense transcript (BACE1 AS) is upregulated along with BACE ̶ ̶ ̶ ̶ ̶ ̶ ̶ Aβ exposure in HEK cells.

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Gene Ontology annotations

Sequence

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GGCUCACCGCAACCUCCACCGUCCUGAGUUAAAGUGAUUCUCCUGUCUCAGCCCCCUGAGUAGCUAGGAUUACAGGCGUGCGCCACCACACCCAGCUAAUUUUUGUACUUUUAGUAGAGAUGGGAUUUCACCCUGUUGGUCAGGCUGGUCUUGAACUCCUGACCUAGUGAUCUGCCCACCUUGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGCCACCACGCCUGGCUAGGGGAAGAGUGUUUUAAGAGCUCUGAGUAGAAGGGUCUAAGUGCAGACAUCUUGGCUGUUGCUGAAGAAUGUGACUCUCACCGCCUCCCUCUGACACUGUACCAUCUCUUUUACCCCCAUCCUUAGUCCACUCACGGAGGAGGCUGCCUUGAUGGAUUUGACUGCAGCUUCAAACACUUUCUUGGGCAAACGAAGGUUGGUGGUGCCACUGUCCACAAUGCUCUUGUCAUAGUUGUACUAAGAGGGAAAAGAGAGAGUUAAAAGAGUCAAAAGGUUUUUGAUGCUGGGCUCUGGGCAGUAGGGGGUUACUGCUGGGGCCCCAGCUGGGUUGGCAUCUUGGCUUUGGCACCUCCUAAGUGUACCUGCUUGGACAAGUUAACCUCUGUGCCUCAGUUCCUUCAUCUCUAAAGUGAGGAUAAAAAUAGCACCUACCUCAAAGGGUUAUUGUAAGGAUUAAAUAAAUCAGCAAUGUAAAGCACUUAGAAUCGUGCCCAGCAGAGAGAAGGCACUUGGUAAAUGUUUAUUCUUGUUAAUCUUGGGUGGGCAGGUAGUCUCCAAACUUGAAAAUAAAAAUACCUUGUUUAGUGCUUUUAAAAAAAAAAAAAAAAA

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Publications