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Homo sapiens (human) IGF2BP2 antisense RNA 1 (IGF2BP2-AS1) URS00007C5419_9606

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IGF2BP2-AS1: IGF2BP2-AS1 is a long non-coding RNA (lncRNA) that has been found to be related to better overall survival in lung squamous cell carcinoma (LUSC) [PMC5617423]. It is also upregulated in oral squamous cell carcinoma (OSCC) and is associated with poor survival in OSCC patients [PMC9552850]. IGF2BP2-AS1 has been shown to inhibit cell growth and migration through the Wnt/β-catenin pathway, suggesting it could be a potential molecular target for OSCC [PMC9552850]. It has been found that IGF2BP2-AS1 and DGCR5 may play roles in LUSC development through similar biological processes [PMC5421846]. The expression of IGF2BP2-AS1 is higher in OSCC compared to normal tissues, indicating its potential involvement in the progression of the disease [PMC9552850]. The coexpression of genes with IGF2BP2-AS1 and DGCR5 clustered within various biological processes, including adhesion, regulation, cellular organization, metabolism, and response to stimulus [PMC5421846]. Furthermore, genes coexpressed with IGF2BP2-AS1 were found to be involved in binding and catalytic activity [PMC5421846]. The combination of IGF2BP2-AS1 and DGCR5 expression could improve patient outcome prediction capability for LUSC [PMC5421846]. Additionally, IGF2BP2-AS1 has been associated with better disease-free survival in LUSC patients compared to other lncRNAs [PMC5421846]. In osteosarcoma patients, IGF2BP2-AS1 was identified as one of the lncRNAs with prognostic value for overall survival prediction [PMC8176230]. Overall, these findings suggest that IGF2BP2-AS1 may have important roles in cancer development and prognosis in various types of cancer [PMC5421846] [PMC8176230].

Genome locations

Gene Ontology annotations

Sequence

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GUUAUUGCGACUUUGAUCUAAACAGCUCUGUAAAGCCCAUUUUCACAUUUUUAAAAUAAUAUGCUUUAGCAGCAGGUGAGGAAAACUUAAGGCAUGGCACAUUUAUUGGAAAAGCAGCAGUGGGCGGCUUGGUUUAAUGGCAACACCACUAGAUAACUGUCUAAGGCCCUUUCCAGAUCCAAUGGUCAAGGUAACAGCAGAAACAAAGAAAAUCUCAGAGGUCUCUUCUUAUGUCUCUGCUAACAAUAAAAAGAACAGCUUUUGGGGAAGUGGGCUGCUUUAUCCUGUAGCCCUCCUCAGAUGCCAAGACUGCUGGGCUGGCCACCAGACUCACGUCCUCAGUAAGGAAUUUACCUCCUACUUUUCUUCGGGGGCAGGUAGGGAAGCACAGCACCAGCCCUCAGCUGUCUUGGGCUCCCUGAUCUGGUUAAGGAGAGUGUAUUUACUCAGGGCCAUGGUGGUGCAUGGAGGAAGCCAACCCUGUCAGCGCUGGCUGGUCAUCAGAAUGGAAGUGGGAGGACAUCCUUCAUUUCCAGGUCAUGCCUGGUUAACAUUUCACCUUAACUGAGGGGCCAAAGAGAGGCUACGCAGCCUGGAUCAGAGCUCCGACAGCCCUUACCUGGUGGCUUGUUCGUGGAAUUUAUCACAUCCUGUUGUAACGCUCUGUUUACAUCUCUGCUGCCCAGCCAGACUCCGCCUUCUGUGAUUUUCUCAUCCCACCACCCAGUACUGUACAUGCUCAAUGGAUGACUAUAAACAAGUGAACAGACAGCAGGAGUGGCUGCCCUUAUGCCCAUGGAACUGGGCCUCUCAAUUCAGCUCAUGUUGGUCAUUUCAGAUCAUCUGAAUGUAAAGGGUCCUCUCUGUCUCUGACCAGGCUUCUUGCAGGCCUUUGGCAGCCGUGGAGCUCUGAGAGAGACUGGUUUCCUGAGGGCUGGGCACCCCGGUCUAUUUAUUGGGAGGCCACAAACAGAAAGAGUGGGCAUCAGGACCAACGGGCACAUGGCCACCACCCAGAUACGUGACUCUGGCAUGUAUUUCACUUCUCUGGGGCCAGAUGGCCUCUUCCUAAGAUUCUCCUCAGUGCUGAGAGUUCUUCAGUCCUGCCUGCUGACUUCCCUCCAGGACAGAACAGAUGCCUCUUCCUCCCAUAGAUAUGAUGCAAGAACUGAGCUGUCCAAGCAAAAAAAAACCUUUGAAGGAAGAAUUUCUGUGCUGUGAGUGGUUUACUCUGAGAAUAGGACUCAAGUUUUAGAAAUCUUUGUUCAAUGUCAGAGAUAGAGCGACUGUAAUCUGUGAGCCAAGAAAAAAGGUUUGUAAAGGCUAGAAGAAAAGAAGCCCAUGGCUAAGAACUUGUAAAAACAUCUACAGCAAACAAGAGUUCCAAGAGAAAGACUGUGAAACAGCAGGCCCACAGGAGCUGGAGAGCGAGCUUUGAAACGAUACAAAAUUAAUUGUCUAAGGGGCAAAUAAAUGGUGCAGUACACAAAUGCAGGAGGUGACACAAACGCACCUGGAUUCAACAGAGGACAAGUAGACACAUCUAUGUCCCAGGCUGCACUAAUGAGGAAAGUCCACCAGGUGGGAAGUAGGUACCACUGAGAGUUUAUAAGGCUAAAAACCCCAGUCUUGGGAUGCGGAGAAGGAGGGAAGGAAGUGAGAAUGAACAGGAAUGGCAUAUUCUGUUCACUUCACUGACAGCUUUGCACUGUGCAUUCCCAGCUGGGCAUGUCCCAGACAUGAUCUCUUGCAUGGGCUGUACUAACGAACAUCAAAUAUUCAGGCUGGCAACCAGUUACAUGAACCGGUGUCAGGAGUGCACAUUAAUAGGCAUCUGACUAGGGCAGGGCUGGGCAAACUACGGCCCCUGCGCUACAUCCAGCCUAAAGCCUGUUUCUGUAAAUAAAGUUUUAUCAAAACACCC

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Publications