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Homo sapiens (human) long intergenic non-protein coding RNA, regulator of reprogramming (LINC-ROR) URS00007681C7_9606

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LINC-ROR: LINC-ROR is a long non-coding RNA (lncRNA) that has been implicated in various biological processes and diseases, including cancer [PMC8413664]. Exosomal LINC-ROR derived from adipocytes has been shown to enhance the motility of pancreatic cancer cell lines [PMC8413664]. LINC-ROR is involved in estrogen-independent growth and may activate the MAPK/ERK pathway [PMC5645922] [PMC8345104]. It can act as a competitive endogenous RNA for miR-138 and miR-145, thereby promoting bone regeneration [PMC8863721]. LINC-ROR also induces epithelial-mesenchymal transition (EMT) and activates the Wnt/β-catenin pathway to promote invasion and metastasis [PMC5642532]. It interacts with protein partners to regulate DEPDC1 expression [PMC8571363]. LINC-ROR is upregulated in various cancers, including liver cancer, breast cancer, pancreatic cancer, and gastrointestinal tract cancers [PMC5553131] [PMC8571363] [PMC6145201] [PMC9965135]. It can regulate p53 pathways and contribute to breast cancer tumorigenesis and metastasis [PMC5312334]. LINC-ROR is transferred via exosomes to trigger EMT in thyroid cancer stem-like cells and liver cancer cells, promoting tumor growth and metastasis [PMC7204309] [PMC9238168]. It also plays a role in chemoresistance by targeting specific genes involved in drug response pathways [PMC6366022] [PMC9306054] [PMC7867499] [PMC5110662] [PMC5799857] [PMC4050189]. LINC-ROR expression has been associated with poor prognosis in various cancers including gastric cancer (GC) [PMC8314397], non-small cell lung carcinoma (NSCLC) [PMC7432147], and non-small cell lung cancer (NSCLC) [PMC7432147]. It has been shown to regulate the expression of transcription factors and microRNAs involved in stem cell biology and reprogramming [PMC3929601] [PMC4381443] [PMC4736767]. LINC-ROR has potential as a diagnostic marker for GC and its downregulation has been observed in GC tissues [PMC8183384] [PMC7607276]. Overall, LINC-ROR is a versatile lncRNA that plays a significant role in various biological processes, including cancer progression, metastasis, drug resistance, and stem cell biology.

Genome locations

Gene Ontology annotations

Sequence

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GGUGAAAUAAACAGCCAUGUUGCUCACACAAAGCCUGUUUGGUGGUCUCUUCACACGGACGCUCAUGAAAUUUGGUGAUGUGACUCGGAUAGGGGGACCUCCCUUGGGAGAUCAGUACCCUGUCCUCCUGCUCUUUGCUCCGUGAGAAAGAUCCACCUACAACCUCAGGUCCUUAGACCAACCAGCCCAAGAAACAUCUCACCAAUUUCAAAUCCAGACCCCACUGGAAAUCGGACUGUCCAACUCACCUGACAGCCACUCCCACAGCCGCUGGAACUCUGGCCCAAGGCUCUCUGACUCCUUCCCAGAUCUUCUUGGCUUAGCGGCUGAAGACUGACGCUGCCCGAUCGCCUCGGAAGCCCCCUAGACCAUCACGGACGCCGAGCUUCGGGUAACUCUCACAGUGGAAGAAACACAACUACAGAUUUCUACCUGGUGCAUGGCCAUCGCUCAUGAAGACUACAACUUCCAGCUUCCUUUGAAGAAAAAGAGGACUUGAUGGCAUUGUCGCUAAGUAAGAAAUAAUGUGUGUGACUUCAGGGUUGCCCCCUUAAAGGGAGGGGACAUUUUCCAUCCUGCUGUUCAGAGUAUGGAUGUGAUGAGAGACAUCUUGGAUGAUGCAGAGGAGGUGAACACCCCAGGACAAUGAAACCACAGGAGAGAAAGAGCCUGCGCUGGCCCAUCUAGCACAGCCACUGGACACAGGGACCACCUGCCUCUGCACUCUUAUGGAAGGAGGAAAUCUAACUUUCCCAGUUUAAGGCACUGUUACUUUGGGCUCCUGUUACAUAACUGUGGCAGAAUGAAGGUUCAACAUGGAAACUGGCAAUGUUGAAGAAACAUAAAGUUCAUUGCUUGAAUAUCUGAAGUUGUGGACUCAAUCUCAUACCUGCUCCACUUAUGAGUUAUAGUUCUUCCAGGUCUCAGGAAUGGGAUCAGCAGGUCUCAGGGUUGUACUCUCCUGGAUCUCUCACCAGCCACCUCAAACCAGCUGCCAUAGCCUGUCCACUUCCACUCCAAUCUUCUCUUCCUUCAUCACCUCCCUUGCACACCCUGAUAACCUCGAAAGAGAACUCUUCCCAAGGCUCUGUUCCAAACACAUCGCCACUCUGCUUAGAACCUUCAAUGACUCCUCAUGGCCUAGGAGGUUUCUCUCCCAUCUGGAUCCAGCUGACGUUCCCAGCACCUUCUCCUGACUCCUGUCUUUUCUUGAACCAGUUCUGCCCAACAAGGAGGAAAGGGCUGACAGAGUGAAAGUCCCAGGGCAUGUGGGAAUGUGACUCUUUUCACUUUAAAUUCUAUGACUGGAAAGUUUUGGGCAGAGUUGGACAUGUGCACUUAGCUUCCAGAAGACAGAAUCCUUUUAAAAGAGUCAGAGAAAACACUGGCUUCCUGCCAUGACAUGAGAUACAGACAGGAGAGUUGGGAAGCUUUUUAAAGAUGGCACUAUGACUACAAUCACAGAAACUCUCCAUGAGGAAGUAAAAGAAAGCACCUGCAACACUCCAGCUAUGCAGACCACUCUGUAAUGGGCUCAGAUCUGGACAGGUGUGUGGAAAGGUGGGUCAACAGGUCAGGCGUCACAGACUUGGAACAUUCAUGGUGGAAAAGAAAAAGCCCCAAAGAAGAGACUUCAGGAUAAAUGAGAAAAUACUCAAGACAGCAAAAGUCUCUUUUAGAAAUGUUGGAGAAAGAACACUUAAUGUCAGGAGUUACUGUUGAUUGAUGGCCUUACUGUGUAGCAGGUGAGAAACCCAUUGUUCAGUUCCCUAAAGUCACCCUAUUCUCCCAAUCAUCCUAUGGAGGGGGAACCAUGAUGGUUAUCCCCAUCUUAUAAAUAAAGCAACAGAGGCUUAGAAGGACGAACUCUUUUUCUCAAGGUUACCCAGAUCAUUUUGCAGAAGUCCCUAGAUUUGAAUCAUGCUCUUGCUUUGAGGUUAAAGACACAGGGGAAGUCGAACUCCUUAUCUCCUAUAUCCUGAAUAGGGAAAACCAAACAUUGUCAAGAGGAGAGGAAGCCUGAGAGUUGGCAUGAAUCAGAGUGCUGGGCAGUCUGGAGUCUUCCCCACUGAGUUGAUGAUGGAACAGUAGAGUGGGGCCUGAGCCCCGUUAGGGCAUGAGCUGCUGAAUGAUUCAUGUGAACACCAUGCACAUGGGAGUGAGGUUUUGAGCAGUGUGCCACAGGAGCCUACCCUCAGGCCCCACCAUAAAAUGUAGGGCCAGUCCUACAUUUUAUCAAUGACUUGCGUGAACACAGAAAAUGUGGAUACAACCAAAAGGUAACAAUCCAAUUAAAAAAUGGACAAAAAACUUGAAUAAACAUUUCUCAAAAGAAGAUAUACAAAUGAUCAAAAAGCAUAUGAAAAAAUGCUCAACAUCGCUAAUUGUAAGAGAAAUGCAAAUCAAAACUAUAAUGAGAUACCACCUUAUAUUGAUUAGGAAGACUGCUAUAAAAAUAGUAAACAAACAAACAAACAAAGUAAGUCUUGGGGAGGAUGCAGAGAAAUUAAAAUUUUUGUGCACUGUUAGUGGGAAUGUAAAAUGGUGCAGCUGUUACGGGAAACGGUAUGACAGUUCCUCAAAAAAUAAAAUGUAGAAACAGC

Taxonomic tree

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Publications