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hsa-mir-6127: Hsa-mir-6127 is a microRNA that has been validated through functional studies to bind to a circRNA, hsa_circ_0045272, and act as a sponge to downregulate apoptosis and IL-2 expression [PMC8599985]. It has also been found to target multiple genes, including UBE2D3, in the context of gestational diabetes mellitus (GDM) [PMC8145272]. However, the specific role of hsa-mir-6127 in cigarette smoking-related pathology has not been reported [PMC8882369]. Hsa_circ_0045272 is suggested to negatively regulate T cell apoptosis and IL-2 secretion through the adsorption of hsa-mir-6127 [PMC9972402]. In the context of GDM, UBE2D3, PAK2, DDB1, DVL3, PSMC4, hsa-mir-6127 (among others) have been identified as novel biomarkers for disease progression [PMC8145272]. Additionally, there are 43 co-targeting miRNAs that include hsa-mir-6127 in their target list [PMC7607069]. Overall, these findings highlight the potential role of hsa-mir-6127 in regulating various cellular processes and its relevance in different disease contexts. However, further research is needed to fully understand its mechanisms and functions.
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Gene Ontology annotations
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